INT238261

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
pma (Mus musculus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 100.00 Very High Very High Very High
cytokine 8 93.92 High High
Spinal cord 114 50.00 Quite Low
Central nervous system 58 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 2 96.08 Very High Very High Very High
Cancer 4 82.08 Quite High
Spinal Cord Injury 140 80.24 Quite High
Injury 114 20.32 Low Low
Central Nervous System Disease 56 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Cicatrix 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed above for C3, mRNA expression of these complement inhibitors by PMNs was also decreased by PMA activation, suggesting that PKC activity enhancement in response to PMA stimulation inhibits PMN expression of CD59 and Crry, and therefore, may contribute to the short lifespan of several days for PMNs.
PMA Positive_regulation (enhancement) of PKC associated with kinase c and lifespan
1) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.25 Pain Relevance 0.16
PMA is a synthetic stimulant that diffuses into the cytoplasm of PMNs and activates protein kinase C (PKC) resulting in the subsequent generation of hydrogen peroxide.
PMA Positive_regulation (activates) of PKC associated with kinase c
2) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.08 Pain Relevance 0.19

General Comments

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