INT2383

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 40
Disease Relevance 25.41
Pain Relevance 15.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CP) oxidoreductase activity (CP) extracellular region (CP)
transmembrane transport (CP)
Anatomy Link Frequency
fat 4
glands 2
Notch 1
plasma 1
erythrocyte 1
CP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 827 100.00 Very High Very High Very High
Chronic pancreatitis 303 100.00 Very High Very High Very High
rheumatoid arthritis 20 99.58 Very High Very High Very High
Inflammation 39 99.04 Very High Very High Very High
Osteoarthritis 8 97.08 Very High Very High Very High
abdominal pain 5 96.86 Very High Very High Very High
Visceral pain 7 95.88 Very High Very High Very High
Mcgill questionnaire 5 95.40 Very High Very High Very High
Analgesic 2 93.32 High High
fibrosis 24 91.24 High High
Disease Link Frequency Relevance Heat
Pain 760 100.00 Very High Very High Very High
Pancreatitis 450 100.00 Very High Very High Very High
Hypertension 4 99.92 Very High Very High Very High
Hemolysis 2 99.82 Very High Very High Very High
Disease 122 99.58 Very High Very High Very High
Rheumatoid Arthritis 20 99.58 Very High Very High Very High
Anaemia 2 99.30 Very High Very High Very High
INFLAMMATION 44 99.04 Very High Very High Very High
Body Weight 73 98.80 Very High Very High Very High
Complex Regional Pain Syndromes 5 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the plasma of RA patients copper and ceruloplasmin levels were found to be significantly increased whereas zinc levels were significantly decreased.
Positive_regulation (increased) of ceruloplasmin in plasma associated with rheumatoid arthritis
1) Confidence 0.67 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8353981 Disease Relevance 1.24 Pain Relevance 0.50
Although the increase in the serum concentration of ceruloplasmin might offer an additional safeguard against oxidative stress. it does not appear to have a beneficial effect upon the activity of the illness as evaluated by means the biological inflammation markers C-reactive protein, erythrocyte sedimentation rate and sialic acid.
Positive_regulation (increase) of ceruloplasmin in erythrocyte associated with stress and inflammation
2) Confidence 0.67 Published 2000 Journal J Trace Elem Med Biol Section Abstract Doc Link 11130855 Disease Relevance 0.54 Pain Relevance 0.25
Alpha-1-antitrypsin, C-reactive protein and ceruloplasmin concentrations were found to be increased in 63%, 50% and 42% of patients with chronic pancreatic disease, respectively.
Positive_regulation (increased) of ceruloplasmin associated with pancreatitis
3) Confidence 0.67 Published 1989 Journal Acta Gastroenterol. Belg. Section Abstract Doc Link 2484737 Disease Relevance 0.80 Pain Relevance 0.17
In the patients, the level of ceruloplasmin was significantly elevated, especially on the side of the pain syndrome and, hence, Lasegue's sign was also more pronounced.
Positive_regulation (elevated) of ceruloplasmin associated with pain
4) Confidence 0.67 Published 1985 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 4002941 Disease Relevance 0.46 Pain Relevance 0.27
In patients without pain lateralization, an increase in ceruloplasmin levels was symmetrical.
Positive_regulation (increase) of ceruloplasmin associated with pain
5) Confidence 0.67 Published 1985 Journal Zh Nevropatol Psikhiatr Im S S Korsakova Section Abstract Doc Link 4002941 Disease Relevance 0.45 Pain Relevance 0.29
A decomposition of the interaction showed that the increase of the CP mean velocity from vision to no vision was similar with and without pain (37% and 43% with and without pain, respectively; planned comparison, p > 0.05).
Positive_regulation (increase) of CP associated with pain
6) Confidence 0.60 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 1.14 Pain Relevance 1.14
The increased variability of the CP amplitude (around the mean position of the CP during a trial) and CP velocity (around the mean velocity of the CP during a trial), the increased range of the postural oscillations and the increased CP mean velocity all suggest a less stable and more variable behavior with than without a noxious heat stimulation.
Positive_regulation (increased) of CP
7) Confidence 0.60 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.57 Pain Relevance 0.54
The copper content and ceruloplasmin activity of serum are significantly elevated above normal values in inflammatory diseases in humans and laboratory animals, and copper in widely different chemical forms is used as therapeutic agent in therapy for chronic and acute inflammation [2].
Positive_regulation (elevated) of ceruloplasmin associated with inflammation and disease
8) Confidence 0.45 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2945467 Disease Relevance 0.86 Pain Relevance 0.33
A ten-year-old boy--complaining of abdominal pain, jaundice, tea-colored urine, and anemia was admitted to this hospital; examination showed Kayser-Fleischer rings, anemia associated with hemolysis, mildly elevated serum transaminases, extremely elevated bilirubin levels, low serum ceruloplasmin level, slightly elevated serum copper, excessive 24-hour urine copper excretion, and severe renal function insufficiencies.
Positive_regulation (elevated) of ceruloplasmin in urine associated with abdominal pain, anaemia, hemolysis and jaundice
9) Confidence 0.45 Published 1990 Journal Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Section Abstract Doc Link 2264486 Disease Relevance 1.46 Pain Relevance 0.10
It was shown that at the acute stage of the disease oxidase activity of ceruloplasmin is increased and depends on the severity, duration and presence of complications.
Positive_regulation (increased) of ceruloplasmin associated with disease
10) Confidence 0.45 Published 2003 Journal Eksp Klin Gastroenterol Section Abstract Doc Link 14653239 Disease Relevance 0.27 Pain Relevance 0.17
Examination of 2 infants on the first day of life revealed abnormal neurological signs, a characteristic hair abnormality, and elevated levels of copper and ceruloplasmin.
Positive_regulation (elevated) of ceruloplasmin in hair
11) Confidence 0.45 Published 1979 Journal Ann. Neurol. Section Abstract Doc Link 426469 Disease Relevance 0.09 Pain Relevance 0.10
For the standard deviation of the CP, the ANOVAs showed an increased CP standard deviation for the Pain conditions for both axes (ps < 0.05).
Positive_regulation (deviation) of CP associated with pain
12) Confidence 0.43 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.53 Pain Relevance 0.53
Overall, the noxious heat stimulation of the lower limbs yielded increased range and standard deviation of the CP trajectory, standard deviation of the CP velocity and mean velocity of the postural oscillations along both axes.



Positive_regulation (increased) of CP in lower limbs
13) Confidence 0.40 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.60 Pain Relevance 0.63
The increase of the CP mean velocity from no vision to no vision co-vibration, however, was greater for the Pain conditions than for the control no-pain conditions (110% and 90% with and without pain, respectively; planned comparison, p < 0.05).
Positive_regulation (increase) of CP associated with pain
14) Confidence 0.40 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 1.10 Pain Relevance 1.10
The increased variability of the CP amplitude (around the mean position of the CP during a trial) and CP velocity (around the mean velocity of the CP during a trial), the increased range of the postural oscillations and the increased CP mean velocity all suggest a less stable and more variable behavior with than without a noxious heat stimulation.
Positive_regulation (increased) of CP
15) Confidence 0.40 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.64 Pain Relevance 0.64
For the standard deviation of the CP, the ANOVAs showed an increased CP standard deviation for the Pain conditions for both axes (ps < 0.05).
Positive_regulation (increased) of CP associated with pain
16) Confidence 0.40 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC270027 Disease Relevance 0.54 Pain Relevance 0.54
The measures of muscular performance (1-RM and RTF total) increased in both the SOmaxP and CP cohorts, though by a higher percentage in the SOmaxP group.
Positive_regulation (increased) of CP
17) Confidence 0.36 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0 Pain Relevance 0
Instead, a 7-fold risk emerged when an elevated level of IgA antibodies to CP in baseline serum was accompanied by factors related to auto-immunity and inflammation, such as elevated levels of h-hsp60 IgA antibodies and CRP.
Positive_regulation (elevated) of CP associated with inflammation
18) Confidence 0.33 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 0.73 Pain Relevance 0.11
Genetic variants that cause higher mesotrypsin activity might increase the risk for CP.
Spec (might) Positive_regulation (increase) of CP associated with chronic pancreatitis
19) Confidence 0.30 Published 2010 Journal Pancreatology Section Abstract Doc Link 20484962 Disease Relevance 0.36 Pain Relevance 0.46
Cold Pressor (CP) pain was induced in 97 healthy participants who precalled CP pain and then reported their actual experiences of CP pain, using the McGill Pain Questionnaire (MPQ) and a Visual Analogue Scale (VAS).
Positive_regulation (induced) of CP associated with pain and mcgill questionnaire
20) Confidence 0.28 Published 2007 Journal J Pain Section Abstract Doc Link 17306627 Disease Relevance 0.99 Pain Relevance 1.22

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