INT238309

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
embryos 2
mesenteric artery 2
Sod1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 5 84.04 Quite High
agonist 20 66.96 Quite High
Bioavailability 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 54 97.00 Very High Very High Very High
Obesity 18 96.24 Very High Very High Very High
Congenital Anomalies 8 85.60 High High
Gestational Diabetes 9 84.68 Quite High
Body Weight 6 77.76 Quite High
Apoptosis 10 50.00 Quite Low
Stress 9 28.72 Quite Low
Insulin Resistance 6 16.88 Low Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found decreased gene expression of CuZnSOD, MnSOD, and Gpx-1 in MD embryos (both nonmalformed embryos of STZ-induced diabetic rats [MDn group] and malformed littermates [MDm group]) compared with N embryos.
Negative_regulation (decreased) of Gene_expression (expression) of CuZnSOD in embryos associated with diabetes mellitus
1) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.45 Pain Relevance 0
The present study is the first to show that physical preconditioning at moderate intensity restores the impairment of relaxing response in mesenteric rings from high caloric diet-fed rats, which was positively associated with reduction in triglycerides concentration and up-regulation in SOD-1 expression.
Negative_regulation (reduction) of Gene_expression (expression) of SOD-1
2) Confidence 0.38 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.46 Pain Relevance 0.09
In mesenteric artery, SOD-1 expression was significantly reduced in SDD animals, but not in aortic rings (Figure 5).


Negative_regulation (reduced) of Gene_expression (expression) of SOD-1 in mesenteric artery
3) Confidence 0.38 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.18 Pain Relevance 0.11

General Comments

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