INT238336

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFA, ADAMTS5) peptidase activity (ADAMTS5) extracellular space (PDGFA)
proteinaceous extracellular matrix (ADAMTS5) embryo development (PDGFA) cell-cell signaling (PDGFA)
PDGFA (Homo sapiens)
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 94.52 High High
Pain 14 89.60 High High
metalloproteinase 8 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 10 5.00 Very Low Very Low Very Low
Rupture 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bone Cancer 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Amputation 1 5.00 Very Low Very Low Very Low
Cadaver 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of EGF, FGF and PDGF had a significant effect on ADAMTS-1 mRNA expression (Fig. 6A), but each induced significant decreases in ADAMTS-5 mRNA levels (P < 0.01, except for PDGF P < 0.05), which were maintained over 48 h (Fig. 6C).
PDGF Regulation (effect) of Negative_regulation (decreases) of ADAMTS-5
1) Confidence 0.04 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.14

General Comments

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