INT238422

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.92
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
HGF 2
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 83.36 Quite High
Inflammation 30 59.20 Quite High
cytokine 15 55.36 Quite High
cINOD 19 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 275 99.58 Very High Very High Very High
Carcinoma 28 99.00 Very High Very High Very High
Apoptosis 175 96.36 Very High Very High Very High
Lymphatic System Cancer 50 88.76 High High
Leukemia 32 88.40 High High
Injury 4 82.28 Quite High
Lung Cancer 8 77.12 Quite High
Hepatocellular Cancer 30 73.84 Quite High
Residual Neoplasm 15 69.32 Quite High
INFLAMMATION 33 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concerning cell cycle, PKB is able to phosphorylate cdk inhibitors, such as p21 and p27, leading to PCNA activation [168, 169].
Positive_regulation (leading) of Positive_regulation (activation) of PCNA
1) Confidence 0.20 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.81 Pain Relevance 0.13
Secondly, residual hepatic VX2 carcinoma might facilitate rapid tumor progression through induction of overexpression of multiple molecular factors, such as PCNA, MMP-9, VEGF, HGF and IL-6.


Positive_regulation (induction) of Positive_regulation (overexpression) of PCNA in HGF associated with cancer and carcinoma
2) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.73 Pain Relevance 0
Immunohistochemistry experiments confirmed these results, since all tumors sections analyzed displayed higher expression levels of the proliferating cell nuclear antigen (PCNA), a processivity factor for DNA polymerase ?
Positive_regulation (higher) of Positive_regulation (levels) of PCNA associated with cancer
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.24 Pain Relevance 0
expression can result in a reduced activity of cyclin/CDK complexes which
Positive_regulation (result) of Positive_regulation (activity) of cyclin
4) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.15 Pain Relevance 0

General Comments

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