INT238422

Context Info Confidence 0.20 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.92 Pain Relevance 0.13

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA) nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)

Anatomy Link Frequency HGF 2 PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 52 83.36 Inflammation 30 59.20 cytokine 15 55.36 cINOD 19 5.00 agonist 8 5.00 antagonist 6 5.00 aspirin 4 5.00 withdrawal 3 5.00 Pain 3 5.00 Paracetamol 3 5.00

Disease Link Frequency Relevance Heat Cancer 275 99.58 Carcinoma 28 99.00 Apoptosis 175 96.36 Lymphatic System Cancer 50 88.76 Leukemia 32 88.40 Injury 4 82.28 Lung Cancer 8 77.12 Hepatocellular Cancer 30 73.84 Residual Neoplasm 15 69.32 INFLAMMATION 33 59.20

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Concerning cell cycle, PKB is able to phosphorylate cdk inhibitors, such as p21 and p27, leading to PCNA activation [168, 169].

Positive_regulation (leading) of Positive_regulation (activation) of PCNA

1) Confidence 0.20 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.81 Pain Relevance 0.13

Secondly, residual hepatic VX2 carcinoma might facilitate rapid tumor progression through induction of overexpression of multiple molecular factors, such as PCNA, MMP-9, VEGF, HGF and IL-6.

Positive_regulation (induction) of Positive_regulation (overexpression) of PCNA in HGF associated with cancer and carcinoma

2) Confidence 0.09 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.73 Pain Relevance 0

Immunohistochemistry experiments confirmed these results, since all tumors sections analyzed displayed higher expression levels of the proliferating cell nuclear antigen (PCNA), a processivity factor for DNA polymerase ?

Positive_regulation (higher) of Positive_regulation (levels) of PCNA associated with cancer

3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.24 Pain Relevance 0

expression can result in a reduced activity of cyclin/CDK complexes which

Positive_regulation (result) of Positive_regulation (activity) of cyclin

4) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.15 Pain Relevance 0

General Comments

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