INT238425

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 75 99.62 Very High Very High Very High
Lymphatic System Cancer 46 89.16 High High
Leukemia 23 88.80 High High
Injury 1 52.88 Quite High
Targeted Disruption 1 50.00 Quite Low
Disease 7 21.72 Low Low
Aging 2 8.68 Low Low
Stress 8 8.48 Low Low
Apoptosis 23 5.00 Very Low Very Low Very Low
Colon Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry experiments confirmed these results, since all tumors sections analyzed displayed higher expression levels of the proliferating cell nuclear antigen (PCNA), a processivity factor for DNA polymerase ?
Negative_regulation (displayed) of Positive_regulation (levels) of PCNA associated with cancer
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.25 Pain Relevance 0
expression can result in a reduced activity of cyclin/CDK complexes which
Negative_regulation (reduced) of Positive_regulation (activity) of cyclin
2) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.15 Pain Relevance 0

General Comments

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