INT238433

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 99.10 Very High Very High Very High
Inflammation 5 95.36 Very High Very High Very High
cytokine 1 94.32 High High
COX2 2 86.84 High High
antagonist 1 37.12 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 95.36 Very High Very High Very High
Small Cell Lung Cancer 63 92.64 High High
Cancer 52 80.92 Quite High
Leukemia 3 68.00 Quite High
Colon Cancer 5 65.04 Quite High
Lung Cancer 11 58.40 Quite High
Reprotox - General 1 5 49.60 Quite Low
Apoptosis 29 46.68 Quite Low
Neuroblastoma 3 26.00 Quite Low
Hepatocellular Cancer 1 10.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, capsaicin-induced growth arrest was associated with a decrease in the expression of the E2F target genes cyclin E, TS, cdc25A and cdc6.
Negative_regulation (decrease) of Gene_expression (expression) of E2F associated with qutenza
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.71 Pain Relevance 0.94
inhibition of E2F/DP DNA binding [129], the inhibition of cyclins D1 and E,
Negative_regulation (inhibition) of Gene_expression (/) of E2F
2) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.30 Pain Relevance 0.14

General Comments

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