INT238439

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDPK1) nucleoplasm (PDPK1) cytoplasmic membrane-bounded vesicle (PDPK1)
plasma membrane (PDPK1) nucleus (PDPK1) kinase activity (PDPK1)
PDPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 3 65.32 Quite High
analgesia 2 63.44 Quite High
opiate 9 62.88 Quite High
palliative 2 60.72 Quite High
antagonist 11 47.56 Quite Low
Breakthrough pain 1 44.56 Quite Low
Pain management 1 42.48 Quite Low
Opioid 5 39.04 Quite Low
narcan 1 33.12 Quite Low
mu opioid receptor 5 30.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer 16 96.72 Very High Very High Very High
Apoptosis 23 94.20 High High
Hepatocellular Cancer 2 84.24 Quite High
Ovarian Cancer 1 82.88 Quite High
Acute Lymphoid Leukemia 1 80.64 Quite High
Colon Cancer 5 73.32 Quite High
Death 2 64.88 Quite High
Breast Cancer 1 57.84 Quite High
Liver Cancer 1 53.48 Quite High
Pain 2 44.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt can also be threonine phosphorylated by PI3 kinase activation of PDK1 [41-45].
Positive_regulation (activation) of PDK1
1) Confidence 0.20 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.31
and upregulation of the 3-phosphoinositide-dependent kinase-1 (PDK1) and
Positive_regulation (upregulation) of PDK1
2) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 1.30 Pain Relevance 0

General Comments

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