INT238440

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.09
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 99.98 Very High Very High Very High
Inflammation 9 96.48 Very High Very High Very High
cytokine 2 95.44 Very High Very High Very High
COX2 4 86.84 High High
antagonist 2 38.24 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 63 99.04 Very High Very High Very High
INFLAMMATION 11 96.48 Very High Very High Very High
Cancer 62 86.76 High High
Leukemia 5 69.12 Quite High
Colon Cancer 10 66.16 Quite High
Lung Cancer 12 51.16 Quite High
Reprotox - General 1 6 50.72 Quite High
Apoptosis 52 46.68 Quite Low
Injury 2 34.44 Quite Low
Neuroblastoma 6 27.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, chromatin IP (ChIP) analysis of human SCLC cells demonstrated that treatment of capsaicin decreased the recruitment of activator E2Fs, namely E2F2 and E2F3, to proliferative promoters like cyclin E, TS, cdc25A and cdc6.
Negative_regulation (decreased) of E2F2 Binding (recruitment) of associated with qutenza and small cell lung cancer
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.65 Pain Relevance 0.94
the phosphorylation of pRb, but also decreases the amount of “free” E2F
Negative_regulation (decreases) of E2F Binding (amount) of
2) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.09 Pain Relevance 0
inhibition of E2F/DP DNA binding [129], the inhibition of cyclins D1 and E,
Negative_regulation (inhibition) of E2F Binding (binding) of
3) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.35 Pain Relevance 0.14

General Comments

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