INT238448

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.07
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Zglp1) DNA binding (Zglp1)
Anatomy Link Frequency
femoral artery 1
brain 1
saliva 1
upper 1
Zglp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 136 87.96 High High
Paracetamol 20 87.84 High High
antagonist 14 86.92 High High
Intracerebroventricular 16 77.24 Quite High
Versed 2 51.84 Quite High
vagus nerve 24 42.80 Quite Low
Inflammatory marker 2 40.12 Quite Low
ischemia 4 35.24 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 10 99.76 Very High Very High Very High
Gastric Motility Disorder 10 99.00 Very High Very High Very High
Monsters 2 98.72 Very High Very High Very High
Diabetes Mellitus 213 97.20 Very High Very High Very High
Hyperglycemia 40 96.72 Very High Very High Very High
Pressure And Volume Under Development 12 93.68 High High
Neuropathic Pain 4 84.64 Quite High
Cv Unclassified Under Development 6 83.12 Quite High
Targeted Disruption 44 76.16 Quite High
Diabetic Nephropathy 2 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, GLP-1 receptors are also expressed in the area postrema of the rat brain, which could interact with circulating GLP-1 (27,28).
GLP-1 Binding (interact) of in brain
1) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.41 Pain Relevance 0.22
GLP-1 relaxed femoral artery in a dose-response manner (23), and GLP-1 is associated with vasodilation induced by acetylcholine (24).
GLP-1 Binding (associated) of in femoral artery associated with increased venous pressure under development
2) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.43 Pain Relevance 0.12
It is now well recognized that gastric emptying (GE) is delayed in perhaps 30% of patients with long-standing T2DM,32 and correlates poorly with the presence and severity of upper GI symptoms.138 In healthy subjects the magnitude of the slowing of GE by exogenous GLP-1 is sufficient to cause ‘gastroparesis’ in ?
GLP-1 Binding (exogenous) of in upper associated with diabetes mellitus and gastric motility disorder
3) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 1.00 Pain Relevance 0.08
It was developed from exendin-4, found in the saliva of the gila monster lizard,55 has approximately 50% homology with human GLP-1, but binds more avidly to GLP-1 receptors, and is resistant to degradation by DPP-4, thus prolonging its duration of effect.56 Exenatide is administered twice daily in a dose of 5 or 10 ?
GLP-1 Binding (binds) of in saliva associated with monsters
4) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 0.24 Pain Relevance 0.15
not cross-react with GLP-1.
GLP-1 Binding (react) of
5) Confidence 0.05 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2443691 Disease Relevance 0 Pain Relevance 0.36

General Comments

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