INT23847

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.67
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
myocytes 1
atrium 1
vesicles 1
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 120 96.96 Very High Very High Very High
agonist 95 92.32 High High
cva 54 90.88 High High
Calcium channel 15 89.48 High High
tetrodotoxin 13 82.40 Quite High
conotoxin 2 66.52 Quite High
Catecholamine 28 62.56 Quite High
depression 16 52.92 Quite High
Serotonin 9 25.96 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spasticity 8 93.32 High High
Cv General 3 Under Development 54 90.88 High High
Hypoxia 68 66.72 Quite High
Targeted Disruption 8 63.56 Quite High
Depression 24 52.92 Quite High
Muscular Spasm 8 48.80 Quite Low
INFLAMMATION 23 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Hot Flashes 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The highly purified vesicles of myocardial sarcolemma oriented outward mainly by the cytoplasmic side are used to show that Ca2+-calmodulin-dependent phosphorylation inhibits passive Ca2+-transport, while R24571, a blocking agent of calmodulin-dependent processes, removes this inhibitory effect.
Phosphorylation (phosphorylation) of Ca2 in vesicles
1) Confidence 0.61 Published 1986 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 2432715 Disease Relevance 0 Pain Relevance 0.08
Thus, downstream effects of conventional, Ca2+-activated PKCs include a direct phosphorylation of p47phox, which leads to membrane translocation of cytosolic components (Fig. 1).


Phosphorylation (phosphorylation) of Ca2
2) Confidence 0.42 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.06 Pain Relevance 0.07
Recent evidence indicates that small GTPase RhoA and its downstream effector, ROCK/Rho-kinase, inhibits MLCP, leading to augmentation of myosin light chain phosphorylation and Ca2+ sensitization in response to vasoconstrictor stimuli (Fig. 3).
Phosphorylation (phosphorylation) of Ca2
3) Confidence 0.29 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 0.42 Pain Relevance 0.13
E2 potentiation of [Ca2+]i oscillations requires ER?
Phosphorylation (oscillations) of Ca2
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.34
Furthermore CCh reduces phosphorylation of the L-type Ca2+ channels and thereby the density of the ICa independently from changes in AP duration [20,21] (see Figure 8).
Phosphorylation (phosphorylation) of Ca2 associated with action potential
5) Confidence 0.04 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.18
Phosphorylation of L-type Ca2+ channels due to tonic activation of adenylate cyclase is not uncommon for the vertebrate atrial tissue and may hold true also for the crucian carp atrium.
Phosphorylation (Phosphorylation) of Ca2 in atrium
6) Confidence 0.04 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.05 Pain Relevance 0.07
Thus, the present findings suggest that CCh-mediated antagonism of the cAMP-dependent signaling pathway results in dephosphorylation of L-type Ca2+ channels and thereby contribute to the decreased force production (see Figure 8).
Phosphorylation (dephosphorylation) of Ca2
7) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.13 Pain Relevance 0.12
The inhibitory effect of CCh on ICa suggests that L-type Ca2+ channels of the crucian carp atrial myocytes are phosphorylated under basal conditions and therefore ICa is susceptible to inhibition by muscarinic receptor mediated dephosphorylation.
Phosphorylation (phosphorylated) of Ca2 in myocytes
8) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.14

General Comments

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