INT238489

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.74
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
plasma 4
LRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 79.36 Quite High
Inflammatory mediators 6 63.76 Quite High
Inflammation 18 26.04 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 82 99.86 Very High Very High Very High
Acute Renal Failure 166 99.28 Very High Very High Very High
Proteinuria 66 99.16 Very High Very High Very High
Burns 148 99.06 Very High Very High Very High
Injury 30 85.36 High High
Renal Disease 10 66.08 Quite High
INFLAMMATION 26 63.36 Quite High
Death 2 42.92 Quite Low
Sepsis 52 22.04 Low Low
Congenital Anomalies 2 19.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Burns septic ARF group plasma induced a significant decrease of megalin expression on tubular cells, suggesting that the impairment of tubular re-adsorption due either to apoptosis or to loss of megalin expression could contribute to proteinuria, resulting in the failure of tubular handling of filtered proteins.
Negative_regulation (loss) of Gene_expression (expression) of megalin in plasma associated with acute renal failure, burns, proteinuria and apoptosis
1) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.31 Pain Relevance 0.07
Burns septic ARF group plasma induced a significant decrease of megalin expression on tubular cells, suggesting that the impairment of tubular re-adsorption due either to apoptosis or to loss of megalin expression could contribute to proteinuria, resulting in the failure of tubular handling of filtered proteins.
Negative_regulation (decrease) of Gene_expression (expression) of megalin in plasma associated with acute renal failure, burns, proteinuria and apoptosis
2) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.44 Pain Relevance 0.07

General Comments

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