INT238495

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 9.51
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TJP1) plasma membrane (TJP1) nucleus (TJP1)
cytoplasm (TJP1)
Anatomy Link Frequency
plasma 6
jejunum 2
PBMC 2
TJP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 98.14 Very High Very High Very High
Central nervous system 84 93.60 High High
alcohol 8 87.84 High High
chemokine 36 86.08 High High
ischemia 45 77.92 Quite High
cytokine 35 77.08 Quite High
Morphine 4 75.36 Quite High
Inflammatory mediators 9 73.44 Quite High
cocaine 8 45.36 Quite Low
Nerve growth factor 4 35.20 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 440 99.70 Very High Very High Very High
Acute Renal Failure 249 99.42 Very High Very High Very High
Burns 222 99.20 Very High Very High Very High
INFLAMMATION 79 98.14 Very High Very High Very High
Infection 139 97.50 Very High Very High Very High
Proteinuria 99 95.12 Very High Very High Very High
Apoptosis 143 92.96 High High
Viral Meningitis 72 91.20 High High
Dementia 68 88.32 High High
Glycosuria 3 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the shortly reperfused jejunum a substantial loss of ZO-1 expression was shown in the sheets of shedded cells, which was accompanied by a decreased cytoplasmatic immunoreactivity of I-FABP.


Negative_regulation (loss) of Gene_expression (expression) of ZO-1 in jejunum
1) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.61 Pain Relevance 0.15
Burns septic ARF group plasma also induced a decreased expression of E-cadherin and pan-cytokeratin epithelial markers (data not shown) and of the tight junction protein ZO-1 (Figure 5G–I).


Negative_regulation (decreased) of Gene_expression (expression) of ZO-1 in plasma associated with acute renal failure and burns
2) Confidence 0.13 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 2.07 Pain Relevance 0.03
After challenge of tubular cells with burns septic ARF group plasma, we observed a marked decrease of ZO-1 expression with a simultaneous alteration of TER.
Negative_regulation (decrease) of Gene_expression (expression) of ZO-1 in plasma associated with acute renal failure and burns
3) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.04 Pain Relevance 0.03
Plasma from septic burns patients also exerted an alteration of tubular cell polarity, a reduced expression of the tight junction protein ZO-1 and of the endocytic receptor megalin.
Negative_regulation (reduced) of Gene_expression (expression) of ZO-1 in Plasma associated with burns
4) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.61 Pain Relevance 0.12
As such Tat reduces the expression of occludin, ZO-1, and ZO-2 in the caveolar compartment of HBMECs.
Negative_regulation (reduces) of Gene_expression (expression) of ZO-1
5) Confidence 0.05 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.13 Pain Relevance 0.29
Furthermore, the pro-inflammatory and IFN-inducible gene products released by HBMEC upon exposure to HIV-1 have been found to down-regulate the expression of tight junction proteins claudin-5, ZO-1, and ZO-2 [112].
Negative_regulation (down) of Gene_expression (expression) of ZO-1 associated with inflammation and acquired immune deficiency syndrome or hiv infection
6) Confidence 0.05 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.75 Pain Relevance 0.11
Furthermore, the pro-inflammatory and IFN-inducible gene products released by HBMEC upon exposure to HIV-1 have been found to down-regulate the expression of tight junction proteins claudin-5, ZO-1, and ZO-2 [112].
Negative_regulation (regulate) of Gene_expression (expression) of ZO-1 associated with inflammation and acquired immune deficiency syndrome or hiv infection
7) Confidence 0.05 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.75 Pain Relevance 0.11
Of note, HIV infection of macrophages increased their expression of the CCL2 receptor, CCR2, and CCL2 mediated transmigration of HIV-infected PBMC reduced tight junction proteins occludin, claudin-1 and ZO-1 expression in a BBB model in vitro [94].
Negative_regulation (reduced) of Gene_expression (expression) of ZO-1 in PBMC associated with acquired immune deficiency syndrome or hiv infection and infection
8) Confidence 0.05 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.56 Pain Relevance 0.20

General Comments

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