INT2385

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Context Info
Confidence 0.68
First Reported 1979
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 57
Total Number 61
Disease Relevance 40.74
Pain Relevance 12.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
macrophage 7
bile 4
plasma 1
smooth muscle 1
brains 1
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 871 100.00 Very High Very High Very High
rheumatoid arthritis 112 99.96 Very High Very High Very High
spinal inflammation 24 99.84 Very High Very High Very High
Bile 45 99.72 Very High Very High Very High
aspirin 45 99.36 Very High Very High Very High
Inflammation 966 99.00 Very High Very High Very High
nud 6 98.76 Very High Very High Very High
anesthesia 54 98.58 Very High Very High Very High
endometriosis 4 98.12 Very High Very High Very High
Inflammatory response 138 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 112 99.96 Very High Very High Very High
Malaria 840 99.84 Very High Very High Very High
Skin Cancer 81 99.84 Very High Very High Very High
Low Back Pain 31 99.84 Very High Very High Very High
Malignant Neoplastic Disease 31 99.62 Very High Very High Very High
Candida Infection 6 99.44 Very High Very High Very High
Colorectal Cancer 95 99.32 Very High Very High Very High
Cancer 516 99.24 Very High Very High Very High
Disease 512 99.04 Very High Very High Very High
INFLAMMATION 1241 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note is the significant increase in MIF levels occurring in the midsecretory phase in women with endometriosis as compared with controls, particularly in infertile patients, as well as in the late secretory phase preceding menstruation.
Gene_expression (levels) of MIF
1) Confidence 0.68 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616746 Disease Relevance 0.08 Pain Relevance 0
In conclusion, MIF expression is increased in ESCC.
Gene_expression (expression) of MIF associated with skin cancer
2) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.76 Pain Relevance 0.43
Whereas bile acids induce MIF expression in ESCC cells, aspirin and NS398 significantly inhibit MIF expression, even in the presence of bile acids, via a COX-independent mechanism.
Gene_expression (expression) of MIF in bile associated with aspirin, bile and skin cancer
3) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.75 Pain Relevance 0.39
The aim of this study was to determine the macrophage migration inhibitory factor (MIF) protein and mRNA expression in esophageal squamous cell carcinoma (ESCC), and the effect of bile acids, aspirin and a selective cyclooxygenase-2 (COX-2) inhibitor, NS398, on MIF expression in ESCC cells in vitro.
Gene_expression (expression) of MIF in bile associated with aspirin, bile and skin cancer
4) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.64 Pain Relevance 0.24
Western blotting was used for the detection of MIF protein expression, and reverse transcription-polymerase chain reaction (RT-PCR) for MIF mRNA expression.
Gene_expression (expression) of MIF mRNA
5) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.75 Pain Relevance 0.24
Whereas bile acids induce MIF expression in ESCC cells, aspirin and NS398 significantly inhibit MIF expression, even in the presence of bile acids, via a COX-independent mechanism.
Gene_expression (expression) of MIF in bile associated with aspirin, bile and skin cancer
6) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.68 Pain Relevance 0.38
Western blotting demonstrated that levels of MIF protein were increased in tumors versus non-malignant tissues, with the expression ratio of MIF over beta-actin of 0.93 +/- 0.21 and 0.57 +/- 0.08, respectively (P = 0.012).
Gene_expression (expression) of MIF associated with malignant neoplastic disease and cancer
7) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.92 Pain Relevance 0.40
On the other hand, aspirin and NS398 significantly decreased MIF protein and mRNA expression, and completely blocked bile acid-induced MIF synthesis in the presence or absence of prostaglandin E(2).
Gene_expression (synthesis) of MIF in bile associated with aspirin and bile
8) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.88 Pain Relevance 0.43
Western blotting was used for the detection of MIF protein expression, and reverse transcription-polymerase chain reaction (RT-PCR) for MIF mRNA expression.
Gene_expression (expression) of MIF protein
9) Confidence 0.67 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.75 Pain Relevance 0.24
We believe that this syntax could be enriched and modified using XSL transformations in order to be compliant with GLIF expression language if needed.
Gene_expression (expression) of GLIF
10) Confidence 0.63 Published 2004 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC375539 Disease Relevance 0 Pain Relevance 0
Macrophage migration inhibitory factor (MIF) is a cytokine produced by neuroendocrine and immune tissues that possesses several characteristics of a neuroendocrine mediator.
Gene_expression (produced) of MIF in Macrophage associated with cytokine
11) Confidence 0.60 Published 2005 Journal Pain Section Abstract Doc Link 15836977 Disease Relevance 0.47 Pain Relevance 0.47
Western blotting demonstrated that levels of MIF protein were increased in tumors versus non-malignant tissues, with the expression ratio of MIF over beta-actin of 0.93 +/- 0.21 and 0.57 +/- 0.08, respectively (P = 0.012).
Gene_expression (levels) of MIF protein associated with malignant neoplastic disease and cancer
12) Confidence 0.58 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.92 Pain Relevance 0.36
In the present study, the plasma levels of MIF and several hormones (cortisol, estradiol, testosterone) were determined to evaluate their mutual behaviour in controls and in chronic pain patients.
Spec (determined) Gene_expression (levels) of MIF in plasma associated with lasting pain
13) Confidence 0.53 Published 2005 Journal Pain Section Abstract Doc Link 15836977 Disease Relevance 0.67 Pain Relevance 0.83
Macrophage migration inhibitory factor expression in the intrauterine endometrium of women with endometriosis varies with disease stage, infertility status, and pelvic pain.
Gene_expression (expression) of migration inhibitory factor in endometrium associated with endometriosis, reprotox - general 3, pain pelvic and disease
14) Confidence 0.53 Published 2006 Journal Fertil. Steril. Section Title Doc Link 16616746 Disease Relevance 0.39 Pain Relevance 0.19
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (overexpressed) of MIF
15) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.53 Pain Relevance 0.04
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of MIF in TEK associated with metalloproteinase
16) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.66 Pain Relevance 0.05
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of MIF
17) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.57 Pain Relevance 0.04
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (underexpression) of MIF
18) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.57 Pain Relevance 0.04
We think that this group belongs to an initial stage of development of neoplasia, because it presents fewer alterations than the second group, and because the behavior of some genes related with the beginning of tumor development such as genes related with DNA repairment, apoptosis, TNF, Fas-L route, checkpoint, remodeling, and maintenance of extracellular matrix, were underexpressed or lost their expression while other genes were overexpressed, such as human macrophage migration inhibitory factor and some cyclin-dependent kinases and cytoskeletal proteins.
Gene_expression (overexpressed) of migration inhibitory factor in macrophage associated with cancer and apoptosis
19) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.19 Pain Relevance 0
We have therefore studied whether serum MIF levels are elevated in patients with AS and whether the levels correlate with oxidative stress markers and disease activity parameters.
Spec (whether) Gene_expression (levels) of serum MIF associated with stress, spinal inflammation and disease
20) Confidence 0.43 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 2.10 Pain Relevance 0.99

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