INT238502

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.70
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 2
blood 1
monocyte 1
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 119 98.20 Very High Very High Very High
cva 2 96.84 Very High Very High Very High
cytokine 81 92.28 High High
Inflammatory mediators 15 77.60 Quite High
agonist 4 69.60 Quite High
Central nervous system 21 52.16 Quite High
Chronic pancreatitis 11 34.28 Quite Low
abatacept 3 9.84 Low Low
chemokine 50 5.00 Very Low Very Low Very Low
imagery 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 90 99.20 Very High Very High Very High
INFLAMMATION 142 98.20 Very High Very High Very High
Cv General 3 Under Development 2 96.84 Very High Very High Very High
Apoptosis 78 89.88 High High
Viral Meningitis 4 85.84 High High
Injury 20 85.28 High High
Cold Sores 367 85.24 High High
Burns 74 84.16 Quite High
Acute Renal Failure 83 83.12 Quite High
Peritonitis 30 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of CD40 was confirmed by FACS analysis (Figure 4G).
Regulation (regulation) of CD40
1) Confidence 0.28 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.66 Pain Relevance 0.09
Thus, targeting CD40 rather than its ligand was considered as an alternative, so as to avoid these thromboembolic complications.
Regulation (targeting) of CD40 associated with cva
2) Confidence 0.16 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.18 Pain Relevance 0.09
We assessed if levels of the maturation marker CD83, costimulatory molecule CD40, and HLA DR on blood MDCs and PDCs were affected by the presence of PDAC.
Regulation (affected) of CD40 in blood associated with adenocarcinoma
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.76 Pain Relevance 0.05
In the same cultures, monocytes showed a corresponding dose-dependent response to HMB-PP at 0.1 nM and higher, as judged by increased forward scatter, down-modulation of CD14, up-regulation of CD40 and CD86, and induction of TRAIL and TNF-?
Regulation (regulation) of CD40 in CD86
4) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.33 Pain Relevance 0.08
also appeared to be the major regulators of cell surface CD14, CD40, and CD86 expression, whereas GM-CSF and IL-4 had only minor effects (Fig. 4B).
Regulation (regulators) of CD40 in CD86
5) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0.03
Recently, it has been shown that the complex of the four glycoproteins gB, gD, gH and gL, which are essential for viral attachment/entry (Fig. 3), expressed on the surface of Cos7 cells mediates monocyte-derived DC recognition via a nucleic acid-independent and TLR-independent pathway, leading to the up-regulation of CD40, CD83, CD86 and HLA-DR and to the production of IFN-?
Regulation (regulation) of CD40 in monocyte
6) Confidence 0.09 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.76 Pain Relevance 0.10

General Comments

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