INT238503

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 4.39
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
plasma 4
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 88.64 High High
Inflammation 18 88.24 High High
Inflammatory mediators 6 54.64 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 82 100.00 Very High Very High Very High
Acute Renal Failure 166 99.72 Very High Very High Very High
Burns 148 99.50 Very High Very High Very High
Death 2 94.96 High High
INFLAMMATION 26 88.24 High High
Injury 30 86.96 High High
Sepsis 52 84.24 Quite High
Nephrotoxicity 2 65.48 Quite High
Proteinuria 66 52.48 Quite High
Disorders Of Creatine Metabolism 14 43.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that burns septic ARF group plasma induced both activation of caspases and up-regulation of Fas on tubular cells.
Positive_regulation (induced) of Regulation (regulation) of Fas in plasma associated with acute renal failure and burns
1) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 2.81 Pain Relevance 0.12
Gene array analysis demonstrated that burns septic ARF group plasma induced an up-regulation of several pro-apoptotic genes such as Fas, Fas-Ligand (Fas-L), Bax and Bak and of positive regulators of apoptosis (Abl1, Gadd45a).
Positive_regulation (induced) of Regulation (regulation) of Fas-L in plasma associated with acute renal failure, burns and apoptosis
2) Confidence 0.38 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.58 Pain Relevance 0.07

General Comments

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