INT238504

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.03
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
CD86 2
plasma 2
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 77 99.36 Very High Very High Very High
chemokine 14 58.00 Quite High
Chronic pancreatitis 20 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 99.36 Very High Very High Very High
Apoptosis 41 97.72 Very High Very High Very High
Adenocarcinoma 180 96.88 Very High Very High Very High
Acute Renal Failure 83 89.40 High High
Burns 74 88.96 High High
Injury 15 78.00 Quite High
Cancer 69 32.00 Quite Low
Uremia 4 26.68 Quite Low
Proteinuria 33 5.00 Very Low Very Low Very Low
Sepsis 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combined plasma induced upregulation of CD40 (median 118, median 98), and CD86, (median 105, median 112), in both MDCs and PDCs.
Positive_regulation (induced) of Positive_regulation (upregulation) of CD40 in plasma
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.62 Pain Relevance 0.03
In addition, the CD40 gene and its transduction factor TRAF-3, as well as the nuclear factor (NF)-kB activator Ripk2 gene, were up-regulated, suggesting an inflammatory activation of tubular cells (Figure 4F).
Positive_regulation (up) of Positive_regulation (regulated) of CD40 gene associated with inflammation
2) Confidence 0.29 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.81 Pain Relevance 0.09
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (increased) of Positive_regulation (levels) of CD40 in CD86
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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