INT238507

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 5.14
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 81.48 Quite High
cytokine 5 80.20 Quite High
Inflammation 10 79.80 Quite High
Inflammatory mediators 3 72.08 Quite High
Somatostatin 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 58 100.00 Very High Very High Very High
Paraganglioma 17 99.56 Very High Very High Very High
Death 19 96.68 Very High Very High Very High
Malignant Neoplastic Disease 7 92.44 High High
Acute Renal Failure 83 91.00 High High
Burns 74 90.56 High High
Neuroendocrine Cancer 8 89.16 High High
Sarcoma 1 86.96 High High
Cancer 40 85.68 High High
INFLAMMATION 13 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oridonin activated the caspase 3–dependent apoptotic pathway through up-regulation of Bax and down-regulation of Bcl-2, which promotes release of cytochrome c (Chen et al. 2005; Liu et al. 2006).
Regulation (regulation) of Regulation (regulation) of Bcl-2 associated with apoptosis
1) Confidence 0.44 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 1.43 Pain Relevance 0
Therefore, we unfortunately have to conclude an immunohistochemical evaluation using bcl-2 or p53 in gangliocytic paraganglioma has a limited prognostic value mostly due to its rarity.
Regulation (evaluation) of Regulation (using) of bcl-2 associated with paraganglioma
2) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.18 Pain Relevance 0.04
Indeed, we observed a down-regulation of the anti-apoptotic protein Bcl-2 and an up-regulation of the pro-apoptotic protein Bax.
Regulation (regulation) of Regulation (regulation) of Bcl-2 associated with apoptosis
3) Confidence 0.12 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 2.54 Pain Relevance 0.12

General Comments

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