INT238507

Context Info Confidence 0.44 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 5.14 Pain Relevance 0.16

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2) intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)

BCL2 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 2 81.48 cytokine 5 80.20 Inflammation 10 79.80 Inflammatory mediators 3 72.08 Somatostatin 5 5.00 cva 3 5.00 Potency 3 5.00 Bile 2 5.00 Pain 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 58 100.00 Paraganglioma 17 99.56 Death 19 96.68 Malignant Neoplastic Disease 7 92.44 Acute Renal Failure 83 91.00 Burns 74 90.56 Neuroendocrine Cancer 8 89.16 Sarcoma 1 86.96 Cancer 40 85.68 INFLAMMATION 13 79.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Oridonin activated the caspase 3–dependent apoptotic pathway through up-regulation of Bax and down-regulation of Bcl-2, which promotes release of cytochrome c (Chen et al. 2005; Liu et al. 2006).

Regulation (regulation) of Regulation (regulation) of Bcl-2 associated with apoptosis

1) Confidence 0.44 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 1.43 Pain Relevance 0

Therefore, we unfortunately have to conclude an immunohistochemical evaluation using bcl-2 or p53 in gangliocytic paraganglioma has a limited prognostic value mostly due to its rarity.

Regulation (evaluation) of Regulation (using) of bcl-2 associated with paraganglioma

2) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.18 Pain Relevance 0.04

Indeed, we observed a down-regulation of the anti-apoptotic protein Bcl-2 and an up-regulation of the pro-apoptotic protein Bax.

Regulation (regulation) of Regulation (regulation) of Bcl-2 associated with apoptosis

3) Confidence 0.12 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 2.54 Pain Relevance 0.12

General Comments

This test has worked.