INT238515

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.40
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (BAG3) cytosol (BAG3) plasma membrane (BAG3)
cytoplasm (BAG3)
Anatomy Link Frequency
kidney 1
BAG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Electroencephalography 72 100.00 Very High Very High Very High
Opioid 1 94.84 High High
agonist 1 77.52 Quite High
Paracetamol 6 75.20 Quite High
Analgesic 3 61.00 Quite High
anticonvulsant 1 18.80 Low Low
alcohol 2 16.76 Low Low
isoflurane 4 14.36 Low Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
gABA 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nephrotoxicity 2 90.72 High High
Cognitive Disorder 8 73.24 Quite High
Targeted Disruption 1 67.80 Quite High
Sleep Disorders 6 59.36 Quite High
Toxicity 3 55.04 Quite High
Syndrome 1 53.84 Quite High
Critical Illness 9 50.00 Quite Low
Delirium 4 39.76 Quite Low
Epilepsy 7 37.28 Quite Low
Overdose 2 8.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not have a useful measure of daytime sleep because our actigraphy data significantly overestimated nocturnal and diurnal sleep quantity [21] and our BIS recording was restricted to the nocturnal period due to patient tolerability.
Localization (recording) of BIS
1) Confidence 0.34 Published 2008 Journal Crit Care Section Body Doc Link PMC2447606 Disease Relevance 0.13 Pain Relevance 0.04
Mono-, bis- and tris-glutathionyl adducts are exported and taken up by the kidney where conversion to mercapturic acids occurs to a variable extent.
Localization (exported) of bis in kidney
2) Confidence 0.16 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.27 Pain Relevance 0.38
Furthermore, the BIS and other heuristic EEG monitoring approaches have been reported to be blind to the effects of a number of anaesthetic agents which are in routine clinical use, including nitrous oxide and the opioids (e.g.
Localization (reported) of BIS associated with opioid and electroencephalography
3) Confidence 0.04 Published 2008 Journal Cogn Neurodyn Section Body Doc Link PMC2585619 Disease Relevance 0 Pain Relevance 0.39

General Comments

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