INT238516

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 99.18 Very High Very High Very High
Bioavailability 2 90.08 High High
headache 3 73.56 Quite High
Morphine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
rapifen 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 2 99.70 Very High Very High Very High
INFLAMMATION 1 99.18 Very High Very High Very High
Critical Illness 9 95.32 Very High Very High Very High
Headache 3 73.56 Quite High
Sleep Disorders 6 64.80 Quite High
Vomiting 1 64.16 Quite High
Dizziness 1 63.84 Quite High
Cirrhosis 1 55.84 Quite High
Delirium 4 31.88 Quite Low
Dementia 1 31.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute inflammatory cascade related to sepsis may adversely affect cytochrome P450 regulation, including CYP1A2 enzyme activity [40,41], and a prolonged reduction in enzyme function in patients recovering from critical illness may have contributed to the high peak concentrations.
Spec (may) Regulation (affect) of Regulation (regulation) of P450 associated with inflammation, critical illness and sepsis
1) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2447606 Disease Relevance 0.73 Pain Relevance 0.27

General Comments

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