INT238522

Context Info Confidence 0.54 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.68 Pain Relevance 0.27

Golgi apparatus (ATG9A) cytoplasm (ATG9A)

Anatomy Link Frequency eye 2 ATG9A (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 93.84 Sicca syndrome 2 64.68 anesthesia 8 62.00 fibrosis 4 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Eyelid Disease 98 100.00 Seborrhea 4 100.00 Radiation Sickness 4 99.08 Conjunctiva Disease 2 98.20 Bullous Skin Disease 2 97.58 Conjunctivitis 2 97.16 Conjunctival Diseases 2 96.82 Rosacea 2 95.36 Sjoegrens Syndrome 2 95.00 Eczema 2 94.66

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The criteria for the diagnosis of simple MGD were described as follows: 1) occluded MG orifices; 2) cloudy or inspissated glandular secretion with lack of clear meibum secretion following the application of moderate digital pressure on the tarsus of the upper and lower eye lid; 3) presence of keratinization or displacement of the mucocutaneous junction; 4) absence of inflammatory lid disease such as blepharitis as well as inflammatory skin disorders such as atopic dermatitis, seborrhea sicca, and acne rosacea; 5) absence of a history of cicatricial eyelid and conjunctival diseases such as trachoma, erythema multiforme, ocular cicatricial pemphigoid, and chemical, thermal, or radiation injury; and 6) absence of excessive meibomian lipid secretion (seborrheic MGD).

Localization (secretion) of MGD in eye associated with conjunctivitis, conjunctiva disease, eyelid disease, radiation sickness, eczema, disease, conjunctival diseases, inflammation, sjoegrens syndrome, bullous skin disease, rosacea and seborrhea

1) Confidence 0.54 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2447817 Disease Relevance 1.84 Pain Relevance 0.16

The criteria for the diagnosis of simple MGD were described as follows: 1) occluded MG orifices; 2) cloudy or inspissated glandular secretion with lack of clear meibum secretion following the application of moderate digital pressure on the tarsus of the upper and lower eye lid; 3) presence of keratinization or displacement of the mucocutaneous junction; 4) absence of inflammatory lid disease such as blepharitis as well as inflammatory skin disorders such as atopic dermatitis, seborrhea sicca, and acne rosacea; 5) absence of a history of cicatricial eyelid and conjunctival diseases such as trachoma, erythema multiforme, ocular cicatricial pemphigoid, and chemical, thermal, or radiation injury; and 6) absence of excessive meibomian lipid secretion (seborrheic MGD).

Localization (simple) of MGD in eye associated with conjunctivitis, conjunctiva disease, eyelid disease, radiation sickness, eczema, disease, conjunctival diseases, inflammation, sjoegrens syndrome, bullous skin disease, rosacea and seborrhea

2) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2447817 Disease Relevance 1.84 Pain Relevance 0.12

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