INT238532

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.61
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
plasma 2
skeletal muscle 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 69 99.76 Very High Very High Very High
cINOD 37 94.20 High High
Inflammation 6 81.52 Quite High
Dorsal horn neuron 12 64.24 Quite High
agonist 5 62.44 Quite High
imagery 55 53.08 Quite High
antagonist 15 51.68 Quite High
substance P 11 50.00 Quite Low
Glutamate 6 27.16 Quite Low
addiction 1 25.88 Quite Low
Disease Link Frequency Relevance Heat
Death 37 88.48 High High
INFLAMMATION 7 81.52 Quite High
Disease 26 68.48 Quite High
Toxicity 8 65.92 Quite High
Drug Induced Neurotoxicity 11 58.64 Quite High
Stress 1 51.04 Quite High
Apoptosis 21 47.44 Quite Low
Depression 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other is downregulation of PDE1 by CaMKII through decreasing the affinity for Ca2+/CaM (Hashimoto et al, 1989), which would facilitate the PP-1 inhibition by phospho-DARPP-32 through augmentation of the PKA activity.
Negative_regulation (decreasing) of Ca2 Binding (affinity) of
1) Confidence 0.29 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Moreover, to reduce interaction of Ca2+ sensing modules with cellular targets, mutant CaM/M13 pairs and the skeletal muscle specific Ca2+ sensing protein troponin were used to engineer novel FCIPs, D3cpv (Palmer et al., 2006) and TN-XXL (Mank et al., 2008), respectively.
Negative_regulation (reduce) of Ca2 Binding (interaction) of in skeletal muscle
2) Confidence 0.28 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.03
oligomers without preventing Ca2+ entry through the plasma membrane, prevent ROS production induced by A?
Negative_regulation (preventing) of Ca2 Binding (entry) of in plasma
3) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.61 Pain Relevance 0.70
In 9 of 15 cells recorded, intracellular solution containing 40 mM BAPTA was used to fully suppress accumulation of intracellular Ca2+ associated with NMDA receptor activation.
Negative_regulation (suppress) of Ca2 Binding (associated) of associated with nmda receptor
4) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.34

General Comments

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