INT238533

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.75
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cyct) transport (Cyct) mitochondrion (Cyct)
Anatomy Link Frequency
cleavage 2
Cyct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 186 97.74 Very High Very High Very High
imagery 76 81.68 Quite High
Glutamate 15 30.24 Quite Low
positron emission tomography 8 26.96 Quite Low
Inflammation 38 5.00 Very Low Very Low Very Low
nMDA receptor 15 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 193 99.60 Very High Very High Very High
Apoptosis 165 98.52 Very High Very High Very High
INFLAMMATION 46 97.46 Very High Very High Very High
Drug Induced Neurotoxicity 52 91.04 High High
Neurodegenerative Disease 20 86.76 High High
Disease 173 86.16 High High
Cancer 40 82.68 Quite High
Cognitive Disorder 19 75.88 Quite High
Stomach Cancer 1 69.56 Quite High
Toxicity 42 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
R-flurbiprofen and salicylate prevent also cytochrome c release induced by A?
Negative_regulation (prevent) of Localization (release) of cytochrome c
1) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.62 Pain Relevance 0.39
As for possible mechanisms underlying its anti-apoptotic action, EGb761 may maintain the integrity of the mitochondrial membrane; prevent cytochrome c release from the mitochondria, thereby blocking the formation of the apoptosome and the apoptotic caspase cascade; enhance the transcription of antiapoptotic Bcl-2-like protein; attenuate the transcription of pro-apoptotic caspase-12; inactivate pro-apoptotic c-Jun N-terminal kinase (JNK), thereby “turning off” downstream target c-Jun; inhibit the cleavage of the key effector protease caspase-3, thereby blocking the execution of apoptosis and prevent nuclear DNA fragmentation, the molecular hallmark of apoptosis [3,7,50].
Negative_regulation (prevent) of Localization (release) of cytochrome c in cleavage associated with apoptosis
2) Confidence 0.57 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 1.30 Pain Relevance 0
In addition, we found that a series of non-steroidal anti-inflammatory drugs (NSAIDs) including salicylate, sulindac sulfide, indomethacin, ibuprofen and R-flurbiprofen depolarize mitochondria and inhibit mitochondrial Ca2+ overload, cytochrome c release and cell death induced by A?
Negative_regulation (inhibit) of Localization (release) of cytochrome c associated with inflammation, cinod and death
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2447871 Disease Relevance 1.06 Pain Relevance 0.30
Furthermore, inhibition of mitochondrial Ca2+ uptake by low concentrations of FCCP inhibit both cytochrome c release and cell death without preventing A?
Negative_regulation (inhibit) of Localization (release) of cytochrome c associated with death
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.61 Pain Relevance 0
We found that 1 µM R-flurbiprofen and 100 µM salicylate prevent cytochrome c release induced by A?
Negative_regulation (prevent) of Localization (release) of cytochrome c
5) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.54 Pain Relevance 0.46
We find that FCCP at 100 nM prevents both cytochrome c release induced by both A?
Negative_regulation (prevents) of Localization (release) of cytochrome c
6) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.42 Pain Relevance 0
Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].
Negative_regulation (prevent) of Localization (release) of cytochrome-C
7) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.21 Pain Relevance 0

General Comments

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