INT238560

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.12
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
Myocytes 1
ventricle 1
neuronal 1
heart 1
kidney 1
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 97.60 Very High Very High Very High
Glutamate receptor 3 93.64 High High
fibrosis 61 83.28 Quite High
cerebral cortex 6 73.28 Quite High
anesthesia 20 54.04 Quite High
ketamine 12 26.44 Quite Low
tetrodotoxin 10 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Left Ventricular Hypertrophy 60 99.28 Very High Very High Very High
Autism 1 98.60 Very High Very High Very High
Hypertrophy 59 97.92 Very High Very High Very High
Nervous System Malformation 1 91.44 High High
Targeted Disruption 32 91.24 High High
Natriuresis 6 88.16 High High
Aids-related Complex 1 85.12 High High
Adhesions 12 84.00 Quite High
Fibrosis 60 83.28 Quite High
Coronary Heart Disease 78 77.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, treatment with siMEF2C did not change the amount of MEF2C transcripts in the kidney.
Regulation (amount) of MEF2C in kidney
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.24 Pain Relevance 0
Injections of siGFP (900 µg/Kg) did not affect MEF2C expression levels in the left ventricle in comparison with phosphate buffer saline (Figure 2B).
Neg (not) Regulation (affect) of MEF2C in ventricle
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
MEF2 factors are important regulators of gene transcription involved in cardiac mitochondriogenesis and energy metabolism[20].
Regulation (regulators) of MEF2
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.35 Pain Relevance 0.07
siRNA targeted to mouse MEF2C gene was designed and synthesized as previously published[18], [19].
Regulation (targeted) of MEF2C
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0.10
Next we investigated whether MEF2C silencing affects the load-induced left ventricular hypertrophy.
Spec (whether) Regulation (affects) of MEF2C associated with left ventricular hypertrophy
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.27 Pain Relevance 0
The effect of MEF2C deficit on bone formation is mediated through interactions with HDAC4 such that the precocious ossification in HDAC4 null animals is mostly rescued by a single allele deletion of MEF2C.
Regulation (effect) of MEF2C
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.38 Pain Relevance 0
As an initial approach, experiments were set to test the efficacy of siMEF2C to knockdown MEF2C in cultured NRVMs (Neonatal Rat Ventricular Myocytes).
Regulation (efficacy) of siMEF2C in Myocytes
7) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.42 Pain Relevance 0.03
Myocyte enhancer factor 2 (MEF2), a family of neuronal activity– and calcium-dependent transcription factors, is also regulated by SUMO conjugation.
Regulation (regulated) of MEF2 in neuronal
8) Confidence 0.19 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.15 Pain Relevance 0.09
Consequently, establishing whether expression of AK082072 transcriptionally regulates Mef2C (Figure 3a), a gene implicated in autism and intellectual disability phenotypes [56,57], warrants detailed investigation.
Spec (whether) Regulation (regulates) of Mef2C associated with autism
9) Confidence 0.19 Published 2010 Journal Genome Biol Section Body Doc Link PMC2926783 Disease Relevance 0.26 Pain Relevance 0.04
Targeted gene disruption revealed Smyd1 to be essential for early cardiac development [14] by acting as a downstream effector of the cardiac transcription factor, MEF2C, in the developing heart [26].
Regulation (effector) of MEF2C in heart
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.05 Pain Relevance 0

General Comments

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