INT238584

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (EPB41) plasma membrane (EPB41) nucleus (EPB41)
protein complex (EPB41) cytoplasm (EPB41)
Anatomy Link Frequency
spine 2
EPB41 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 20 87.80 High High
cerebral cortex 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
GABAergic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Cleft Palate 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Stroke 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because SUMOylation of CASK regulates the interaction between CASK and protein 4.1 and because the interaction with protein 4.1 is required for CASK function in spinogenesis, we then investigated whether CASK SUMOylation modulates spine formation.
Positive_regulation (required) of protein 4.1 Binding (interaction) of in spine
1) Confidence 0.49 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0.24
We then wondered whether the CASK protein 4.1–binding site is also required for spinogenesis.
Spec (whether) Positive_regulation (required) of protein 4.1 Binding (binding) of
2) Confidence 0.49 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0

General Comments

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