INT238588

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 9 70.84 Quite High
tetrodotoxin 30 5.00 Very Low Very Low Very Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 3 88.76 High High
Adhesions 18 66.24 Quite High
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Cleft Palate 6 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SUMOylation of CASK modulates the interaction between CASK and protein 4.1, which may therefore down-regulate the association between CASK and the actin cytoskeleton.
Regulation (regulate) of CASK Binding (association) of
1) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.15 Pain Relevance 0.07
Because SUMOylation usually modifies target protein–protein interaction, distribution, or activity, we wondered whether CASK is SUMOylated and whether CASK SUMOylation affects the interaction between CASK and protein 4.1 and thus regulates the function of CASK in spinogenesis.
Spec (whether) Regulation (affects) of CASK Binding (interaction) of
2) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
We then wondered whether CASK SUMOylation regulates the interaction between CASK and protein 4.1.
Spec (whether) Regulation (regulates) of CASK Binding (interaction) of
3) Confidence 0.26 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0

General Comments

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