INT238589

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Anatomy Link Frequency
spine 1
synapse 1
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 6 99.30 Very High Very High Very High
tetrodotoxin 30 93.80 High High
GABAergic 3 50.80 Quite High
Glutamate receptor 9 7.52 Low Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 77.76 Quite High
Adhesions 18 5.00 Very Low Very Low Very Low
Cleft Palate 6 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because CASK is involved in synaptic targeting of N-type calcium channels (Maximov and Bezprozvanny, 2002), phosphorylation of CASK by CDK5 modulates presynaptic calcium influx and controls synapse formation (Samuels et al., 2007).
Phosphorylation (phosphorylation) of CASK in synapse associated with calcium channel
1) Confidence 0.77 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.08 Pain Relevance 0.12
SUMOylation of CASK influences spine morphogenesis
Phosphorylation (SUMOylation) of CASK in spine
2) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0.31
In addition to spinogenesis, CASK also acts presynaptically to regulate synaptogenesis through a different mechanism: CDK5 phosphorylates residues S51 and S395 of CASK proteins, which enhances the interaction between CASK and N-type calcium channels but impairs the interaction between CASK and liprin-?
Phosphorylation (phosphorylates) of CASK associated with calcium channel
3) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.05 Pain Relevance 0.09

General Comments

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