INT238593

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Anatomy Link Frequency
spine 2
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 50 5.00 Very Low Very Low Very Low
cerebral cortex 15 5.00 Very Low Very Low Very Low
Glutamate receptor 15 5.00 Very Low Very Low Very Low
midbrain 10 5.00 Very Low Very Low Very Low
Calcium channel 10 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
GABAergic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 30 88.80 High High
Cleft Palate 10 83.32 Quite High
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 5 5.00 Very Low Very Low Very Low
Aids-related Complex 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Stroke 5 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, a K679R mutation inhibited CASK SUMOylation (Fig. 4 D) and indicated that residue K679 is the SUMOylation site of rat CASK protein.


Negative_regulation (inhibited) of CASK
1) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Longer incubation times, such as 3 or 5 d after transfection of CASK shRNA, did not appear to further reduce the CASK protein levels (Fig.
Negative_regulation (reduce) of CASK
2) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.16 Pain Relevance 0
CASK SUMOylation reduces the interaction between CASK and protein 4.1
Negative_regulation (reduces) of CASK
3) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Knockdown of CASK in cultured hippocampal neurons reduces spine density and shrinks dendritic spines.
Negative_regulation (Knockdown) of CASK in spine
4) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2447900 Disease Relevance 0.16 Pain Relevance 0
p4.1 mutant did not rescue the spine phenotype seen in CASK knockdown (Fig. 3, C and D).
Negative_regulation (knockdown) of CASK in spine
5) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0

General Comments

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