INT238597

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 16
Disease Relevance 0.88
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Anatomy Link Frequency
spine 16
plasma 2
neurons 2
cerebral cortex 2
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 48 99.70 Very High Very High Very High
Glutamate receptor 48 73.72 Quite High
GABAergic 16 51.72 Quite High
tetrodotoxin 160 47.04 Quite Low
Calcium channel 32 24.44 Low Low
midbrain 32 5.00 Very Low Very Low Very Low
Neurotransmitter 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 16 95.16 Very High Very High Very High
Adhesions 96 92.24 High High
Targeted Disruption 96 90.36 High High
Aids-related Complex 16 78.12 Quite High
Cleft Palate 32 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 16 5.00 Very Low Very Low Very Low
Stroke 16 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the cerebral cortex, some neurons express higher levels of CASK, whereas other neurons express very low levels of CASK (Hsueh et al., 1998).
Positive_regulation (levels) of Gene_expression (express) of CASK in cerebral cortex associated with cerebral cortex
1) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.33 Pain Relevance 0.11
Overexpression of the CASK PDZ domain or CASK?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CASK
2) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Similar to the results in Fig. 3 (C and D), overexpression of CASK significantly increased the spine density compared with vector control (D = 0.334 and P < 0.001; Fig. 8).
Positive_regulation (overexpression) of Gene_expression (overexpression) of CASK in spine
3) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Similar to the results using CASK shRNA, overexpression of the CASK PDZ domain also resulted in fewer, shorter, and smaller spines compared with vector control (KS test; for density, D = 0.456 and P < 0.001; for length, D = 0.135 and P = 0.011; for width, D = 0.115 and P = 0.047; Fig. 3, A and B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of CASK in spines
4) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Instead, a CASK mutant lacking the protein 4.1–binding motif was introduced into cultured hippocampal neurons (Fig. 3 A), and quantitative analyses showed that compared with GFP alone, overexpression of this CASK?
Positive_regulation (overexpression) of Gene_expression (overexpression) of CASK in neurons
5) Confidence 0.57 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Our analysis of the time course of RNA interference and CASK overexpression experiments further suggests that CASK stabilizes or maintains spine morphology.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CASK in spine
6) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2447900 Disease Relevance 0.16 Pain Relevance 0
To identify the SUMOylation site of CASK, a series of CASK domain deletion mutants (Fig. 4 A) were cotransfected with Myc-tagged SUMO1 into COS cells.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of CASK
7) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Whether SUMO1, SUMO2, or SUMO3 are conjugated to CASK proteins was investigated by cotransfecting CASK and Myc-tagged SUMOs into COS cells followed by immunoprecipitation using CASK antibody.
Spec (investigated) Positive_regulation (cotransfecting) of Gene_expression (cotransfecting) of CASK
8) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
However, CASK overexpression did not appear to further enlarge spine heads (Fig. 3, C and D).
Positive_regulation (overexpression) of Gene_expression (overexpression) of CASK in spine
9) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Overexpression of a CASK–SUMO1 fusion construct, which mimicks CASK SUMOylation, impairs spine formation.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CASK in spine
10) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2447900 Disease Relevance 0.16 Pain Relevance 0
A prominent Myc tag immunoreactivity was present in the product precipitated by CASK antibody from cells cotransfected with CASK and Myc-SUMO1 (Fig. 4 B, bottom; arrow).
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of CASK
11) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Similar to the results in Fig. 3 (C and D), overexpression of CASK significantly increased the spine density compared with vector control (D = 0.334 and P < 0.001; Fig. 8).
Positive_regulation (increased) of Gene_expression (overexpression) of CASK in spine
12) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
When CASK was overexpressed, the spine density was increased (nonsilencing control + vector control vs. nonsilencing control + CASK; D = 0.406 and P < 0.001; Fig. 3, C and D).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CASK in spine
13) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Overexpression of the CASK PDZ domain or CASK?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CASK
14) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
When CASK was overexpressed, the spine density was increased (nonsilencing control + vector control vs. nonsilencing control + CASK; D = 0.406 and P < 0.001; Fig. 3, C and D).
Positive_regulation (increased) of Gene_expression (overexpressed) of CASK in spine
15) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Because overexpression of C-SUMO1-CASK impairs dendritic spine morphology, it suggests that SUMO1 conjugation leads to dissociation of CASK from postsynaptic plasma membrane.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SUMO1-CASK in plasma
16) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.23 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox