INT2386

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 12
Speculated 2
Reported most in Body
Documents 112
Total Number 116
Disease Relevance 45.46
Pain Relevance 22.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
brain 13
mammary gland 7
brainstem 4
uterus 4
endometrium 3
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 38 100.00 Very High Very High Very High
Somatostatin 471 99.80 Very High Very High Very High
agonist 330 99.78 Very High Very High Very High
antagonist 260 99.76 Very High Very High Very High
Dopamine 698 99.72 Very High Very High Very High
medulla 32 99.68 Very High Very High Very High
carpal tunnel syndrome 8 99.24 Very High Very High Very High
alcohol 36 99.08 Very High Very High Very High
Dynorphin 15 99.08 Very High Very High Very High
amygdala 522 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 227 100.00 Very High Very High Very High
Stress 81 100.00 Very High Very High Very High
Cancer 1067 99.98 Very High Very High Very High
Endometriosis (extended) 101 99.84 Very High Very High Very High
Endometriosis 71 99.84 Very High Very High Very High
Nociception 21 99.76 Very High Very High Very High
Necrosis 43 99.46 Very High Very High Very High
Carpal Tunnel Syndrome 8 99.24 Very High Very High Very High
Ganglion Cysts 10 98.96 Very High Very High Very High
Signet Ring Cell Carcinoma 5 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Progesterone receptor expression in the brainstem of the female rat.
Gene_expression (expression) of Progesterone receptor in brainstem associated with medulla
1) Confidence 0.78 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10568505 Disease Relevance 0 Pain Relevance 0.40
By using in situ hybridization and immunohistochemistry, the presence of neurons expressing progesterone receptor mRNA (PR mRNA) and progesterone receptor-like immunoreactivity (PR-LI) was examined in the brainstem and spinal cord of female rats.
Gene_expression (expressing) of progesterone receptor mRNA in brainstem associated with medulla and spinal cord
2) Confidence 0.78 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10568505 Disease Relevance 0 Pain Relevance 0.36
By using in situ hybridization and immunohistochemistry, the presence of neurons expressing progesterone receptor mRNA (PR mRNA) and progesterone receptor-like immunoreactivity (PR-LI) was examined in the brainstem and spinal cord of female rats.
Gene_expression (expressing) of PR mRNA in brainstem associated with medulla and spinal cord
3) Confidence 0.78 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10568505 Disease Relevance 0 Pain Relevance 0.36
Neurons expressing PR mRNA and PR-LI were seen in the ventrolateral medulla, the parvocellular reticular formation and the nucleus of the solitary tract.
Gene_expression (expressing) of PR mRNA in medulla associated with medulla
4) Confidence 0.78 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10568505 Disease Relevance 0 Pain Relevance 0.40
Second, to our knowledge, no data exist on the presence of the progesterone-receptor (PR) in SOM cells in the hypothalamus.
Gene_expression (presence) of progesterone-receptor in hypothalamus associated with somatostatin
5) Confidence 0.75 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.55
In metastatic endometrial cancer, hormonal therapy is the first choice in tumours expressing a progesterone receptor.
Gene_expression (expressing) of progesterone receptor associated with endometriosis (extended) and cancer
6) Confidence 0.74 Published 2000 Journal Drugs Aging Section Abstract Doc Link 10933513 Disease Relevance 0.97 Pain Relevance 0.09
The tumor was highly positive for estrogen receptor (ER) expression (95%), but less than 10% positive for progesterone receptor (PR) expression.
Gene_expression (expression) of progesterone receptor associated with cancer
7) Confidence 0.72 Published 2008 Journal Cases J Section Body Doc Link PMC2565669 Disease Relevance 1.38 Pain Relevance 0.10
The tumor was highly positive for estrogen receptor (ER) expression (95%), but less than 10% positive for progesterone receptor (PR) expression.
Gene_expression (expression) of PR associated with cancer
8) Confidence 0.72 Published 2008 Journal Cases J Section Body Doc Link PMC2565669 Disease Relevance 1.32 Pain Relevance 0.10
The potency of Group A compounds, but not Group B or C compounds, for ECG actions indicative of Na(+) channel blockade (prolongation of PR and QRS intervals) were significantly increased under "simulated ischaemic" conditions ([K(+)] 10 mM and pH 6.4) in isolated rat hearts.
Gene_expression (actions) of PR in hearts associated with potency
9) Confidence 0.64 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10862826 Disease Relevance 0.15 Pain Relevance 0.12
By using in situ hybridization and immunohistochemistry, the presence of neurons expressing progesterone receptor mRNA (PR mRNA) and progesterone receptor-like immunoreactivity (PR-LI) was examined in the brainstem and spinal cord of female rats.
Gene_expression (expressing) of progesterone receptor-like immunoreactivity in brainstem associated with medulla and spinal cord
10) Confidence 0.60 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10568505 Disease Relevance 0 Pain Relevance 0.38
Because the oestrogen and progesterone receptor were negative in the tumoral tissue, the patient underwent chemotherapy followed by modified radical mastectomy, chemotherapy, and palliative resection of the metastatic mass.
Neg (negative) Gene_expression (negative) of progesterone receptor associated with palliative
11) Confidence 0.57 Published 2005 Journal Acta Chir. Belg. Section Abstract Doc Link 15906923 Disease Relevance 1.10 Pain Relevance 0.22
The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats.
Gene_expression (expression) of progesterone receptor in preoptic area associated with enkephalin
12) Confidence 0.47 Published 2001 Journal Neuroendocrinology Section Title Doc Link 11474214 Disease Relevance 0 Pain Relevance 0.20
Also, since ER regulates synthesis of the progesterone receptor (PR), it is possible that antagonism of ER by tamoxifen results in PR downregulation and that PR may be involved in exocytosis of glycogen from the vaginal epithelium.
Gene_expression (synthesis) of progesterone receptor in epithelium
13) Confidence 0.46 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.05 Pain Relevance 0
Also, since ER regulates synthesis of the progesterone receptor (PR), it is possible that antagonism of ER by tamoxifen results in PR downregulation and that PR may be involved in exocytosis of glycogen from the vaginal epithelium.
Gene_expression (synthesis) of PR in epithelium
14) Confidence 0.46 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.05 Pain Relevance 0
The PR mRNA levels do not vary in the rat uterus during the estrous cycle, suggesting that the expression of PR is primarily regulated post-translationally and/or translationally [30].
Gene_expression (expression) of PR in uterus
15) Confidence 0.44 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.07 Pain Relevance 0
Therefore, epithelial PR expression (especially glandular) in the uterus is likely to be, at least partly, regulated via ER?.


Gene_expression (expression) of epithelial PR in uterus
16) Confidence 0.44 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.21 Pain Relevance 0
Dramatic changes in PR expression have been shown during the estrous cycle and in early pregnancy [8].
Gene_expression (expression) of PR
17) Confidence 0.44 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.11 Pain Relevance 0
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Spec (determined) Gene_expression (expression) of progesterone receptor in mammary gland
18) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.22 Pain Relevance 0.09
Cells expressing both proliferating cell nuclear antigen (PCNA) protein and PR protein were quantified after immunohistochemical staining.
Gene_expression (expressing) of PR
19) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.23 Pain Relevance 0.17
In agreement with our data, they observed estrogenic effects of GEN in the mammary gland (PR expression was increased) and a mild uterotrophic effect of GEN.
Gene_expression (expression) of PR in mammary gland
20) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.09 Pain Relevance 0

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