INT238600

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Anatomy Link Frequency
spine 2
neurons 1
head 1
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 7 16.96 Low Low
tetrodotoxin 70 5.00 Very Low Very Low Very Low
cerebral cortex 21 5.00 Very Low Very Low Very Low
Glutamate receptor 21 5.00 Very Low Very Low Very Low
midbrain 14 5.00 Very Low Very Low Very Low
Calcium channel 14 5.00 Very Low Very Low Very Low
GABAergic 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 42 63.28 Quite High
Adhesions 42 5.00 Very Low Very Low Very Low
Cleft Palate 14 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 7 5.00 Very Low Very Low Very Low
Aids-related Complex 7 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Stroke 7 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then wonder whether the activity of CASK in spinogenesis is regulated by posttranslational modification.
Spec (whether) Regulation (regulated) of CASK
1) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
The effect of these CASK mutants in spine morphology was also examined in the presence of CASK shRNA.
Spec (examined) Regulation (effect) of CASK in spine
2) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Instead, a CASK mutant lacking the protein 4.1–binding motif was introduced into cultured hippocampal neurons (Fig. 3 A), and quantitative analyses showed that compared with GFP alone, overexpression of this CASK?
Regulation (introduced) of CASK mutant in neurons
3) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
However, there were no significant differences in cumulative probability distribution between CASK shRNA and nonsilencing control in the length and width of spines (KS test; for length, D = 0.034 and P = 0.344; for width, D = 0.017 and P = 0.978; Fig. 2, B and C).
Regulation (control) of CASK shRNA in spines
4) Confidence 0.26 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
We also investigate whether the function of CASK in spinogenesis is regulated by posttranslational modification.
Spec (whether) Regulation (regulated) of CASK
5) Confidence 0.26 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.06 Pain Relevance 0
Because SUMOylation usually modifies target protein–protein interaction, distribution, or activity, we wondered whether CASK is SUMOylated and whether CASK SUMOylation affects the interaction between CASK and protein 4.1 and thus regulates the function of CASK in spinogenesis.
Spec (whether) Regulation (regulates) of CASK
6) Confidence 0.26 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Overexpression of a CASK silent mutant, which was not affected by CASK shRNA (Fig. 1 B), rescued the inhibitory effect of CASK shRNA on spine density (KS test; shRNA vs. shRNA + mutant, D = 0.221 and P = 0.05; nonsilencing vs. shRNA + mutant, D = 0.109 and P = 0.774), spine length (KS test; shRNA vs. shRNA + mutant, D = 0.299 and P < 0.001; nonsilencing vs. shRNA + mutant, D = 0.051 and P = 0.32), and width of the spine head (KS test; shRNA vs. shRNA + mutant, D = 0.17 and P < 0.001; nonsilencing vs. shRNA + mutant, D = 0.048 and P = 0.38; Fig. 1, D and E), indicating a specific effect of CASK shRNA.
Regulation (effect) of CASK shRNA in head
7) Confidence 0.26 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0

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