INT238611

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.67
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Anatomy Link Frequency
nucleus 1
synapses 1
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 18 89.16 High High
cerebral cortex 18 73.20 Quite High
GABAergic 6 67.16 Quite High
Calcium channel 12 39.88 Quite Low
tetrodotoxin 60 5.00 Very Low Very Low Very Low
midbrain 12 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 95.36 Very High Very High Very High
Aids-related Complex 6 85.32 High High
Apoptosis 6 81.20 Quite High
Adhesions 36 72.88 Quite High
Stroke 6 50.48 Quite High
Cleft Palate 12 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 6 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because SUMOylation has been suggested to regulate nuclear translocation (for reviews seeWilson and Rangasamy, 2001; Pichler and Melchior, 2002) and because CASK is able to enter the nucleus and regulate gene expression (Hsueh et al., 2000), we examined whether SUMOylation of CASK promotes the nuclear translocation of CASK.
Localization (translocation) of CASK in nucleus
1) Confidence 0.76 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Although SUMOylated CASK proteins were still localized at synapses, they did not appear to be associated with the synaptic membrane.
Localization (localized) of CASK in synapses
2) Confidence 0.76 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.21 Pain Relevance 0.07
To perform immunoprecipitation of CASK, transfected COS cells were first washed with PBS.
Localization (immunoprecipitation) of CASK
3) Confidence 0.71 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.05 Pain Relevance 0
Similar to wild-type CASK, the majority of K679R, C-SUMO1-CASK, and NC-SUMO1-CASK mutants were still present in the cytoplasm of transfected COS cells (Fig. 5 A), indicating that SUMOylation does not trigger the nuclear translocation of CASK.
Localization (translocation) of CASK
4) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
Nuclear distribution of CASK was then examined by immunofluorescence staining and confocal analysis.
Spec (examined) Localization (distribution) of CASK
5) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0
For CASK, it is also possible that molecular redundancy among CASK and other MAGUK proteins (for review see Hsueh, 2006) play a role in modulating the spinogenesis phenotype of CASK knockout mice.
Localization (redundancy) of CASK associated with targeted disruption
6) Confidence 0.62 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.40 Pain Relevance 0.11

General Comments

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