INT238614

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sumo1) transcription factor binding (Sumo1) cytoplasm (Sumo1)
Anatomy Link Frequency
spine 2
Sumo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 30 5.00 Very Low Very Low Very Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
Glutamate receptor 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 18 92.24 High High
Cytomegalovirus Infection 3 91.84 High High
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Cleft Palate 6 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of a CASKĀ–SUMO1 fusion construct, which mimicks CASK SUMOylation, impairs spine formation.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of SUMO1 in spine
1) Confidence 0.29 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2447900 Disease Relevance 0.16 Pain Relevance 0
The pairs of primers used for construction of C- and CN-SUMO1-CASK were as follows: (1) for the fragment in which SUMO1 was deleted in the C-terminal GG region, 5?
Positive_regulation (follows) of Gene_expression (deleted) of SUMO1
2) Confidence 0.29 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.09 Pain Relevance 0
To identify the SUMOylation site of CASK, a series of CASK domain deletion mutants (Fig. 4 A) were cotransfected with Myc-tagged SUMO1 into COS cells.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of SUMO1
3) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0

General Comments

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