INT238618

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.40
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cask) nucleolus (Cask) plasma membrane (Cask)
nucleus (Cask) intracellular (Cask) protein complex assembly (Cask)
Anatomy Link Frequency
cerebral cortex 1
spine 1
synapse 1
Cask (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 9 99.40 Very High Very High Very High
tetrodotoxin 30 86.52 High High
Glutamate receptor 9 73.12 Quite High
GABAergic 3 51.12 Quite High
Calcium channel 6 23.84 Low Low
midbrain 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 94.56 High High
Targeted Disruption 18 89.76 High High
Adhesions 18 71.68 Quite High
Cleft Palate 6 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the cerebral cortex, some neurons express higher levels of CASK, whereas other neurons express very low levels of CASK (Hsueh et al., 1998).
Positive_regulation (levels) of CASK in cerebral cortex associated with cerebral cortex
1) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.33 Pain Relevance 0.11
The interactions with these synaptogenic factors suggest a potential role of PSD-95 and CASK in synapse formation.
Positive_regulation (role) of CASK in synapse
2) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0.07 Pain Relevance 0
Because SUMOylation of CASK regulates the interaction between CASK and protein 4.1 and because the interaction with protein 4.1 is required for CASK function in spinogenesis, we then investigated whether CASK SUMOylation modulates spine formation.
Positive_regulation (required) of CASK in spine
3) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0.24

General Comments

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