INT238641

Context Info Confidence 0.07 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.84

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

TNF (Homo sapiens) Ifx (Mus musculus)

Pain Link Frequency Relevance Heat Infliximab 35 100.00 Etanercept 31 100.00 Adalimumab 8 100.00 Crohn's disease 14 88.08 Inflammation 5 55.28 Inflammatory stimuli 1 50.64 cytokine 3 46.12 imagery 2 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Disease 16 87.44 Apoptosis 48 79.32 Ileitis 1 74.04 INFLAMMATION 6 55.28 Liver Failure 1 34.52 Colitis 36 30.48 Inflammatory Bowel Disease 3 23.72 Targeted Disruption 2 5.00 Necrosis 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

; however, membrane-bound TNF is not, or less, recognized by ETC 28, whereas IFX and ADA also bind to this uncleaved form.

TNF Binding (bind) of IFX associated with infliximab, adalimumab and etanercept

1) Confidence 0.07 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.86 Pain Relevance 0.84

General Comments

This test has worked.