INT238664

Context Info Confidence 0.02 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.63 Pain Relevance 0

cytosol (Fbp1) carbohydrate metabolic process (Fbp1) cytoplasm (Fbp1)

Anatomy Link Frequency Liver 1 Fbp1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 18 26.16 antagonist 14 5.00 Somatostatin 4 5.00 Kinase C 3 5.00 vagus nerve 2 5.00 Piles 2 5.00 alcohol 1 5.00 Calcium channel 1 5.00 depression 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Hepatocellular Cancer 2 73.36 Liver Disease 27 72.72 Hepatitis B Virus Infection 1 71.28 Starvation 1 71.28 Hepatitis C Virus Infection 1 70.88 Hyperphagia 1 44.84 Targeted Disruption 54 41.00 Disease 21 28.32 Impaired Glucose Tolerance 20 26.16 Obesity 49 10.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The activity of the key gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and G6Pase is regulated by transcriptional and nontranscriptional mechanisms, whereas the third key enzyme fructose-1,6-bisphosphatase (FBPase) is also regulated through competitive inhibition by fructose 2,6-bisphosphate.

Regulation (regulated) of FBPase

1) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.21 Pain Relevance 0

Another way to assess the sensitivity of the QUOTE-Liver may be to administer it in two different settings, a specialized setting and a less specialized setting.

Regulation (sensitivity) of QUOTE-Liver in Liver

2) Confidence 0.01 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2453127 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.