INT238712

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.49
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PCBD1) small molecule metabolic process (PCBD1) lyase activity (PCBD1)
nucleolus (PCBD1) nucleus (PCBD1) cellular nitrogen compound metabolic process (PCBD1)
PCBD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hyperalgesia 46 99.76 Very High Very High Very High
Pain 72 99.50 Very High Very High Very High
Inflammation 74 99.42 Very High Very High Very High
c fibre 22 98.70 Very High Very High Very High
Cold hyperalgesia 20 96.24 Very High Very High Very High
Pain threshold 66 91.84 High High
burning pain 4 50.12 Quite High
Quantitative sensory testing 28 5.00 Very Low Very Low Very Low
depression 10 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 70 99.76 Very High Very High Very High
Pain 134 99.50 Very High Very High Very High
INFLAMMATION 60 99.42 Very High Very High Very High
Reflex Sympathetic Dystrophy 264 98.44 Very High Very High Very High
Nociception 12 96.24 Very High Very High Very High
Disease 26 38.08 Quite Low
Neurogenic Inflammation 16 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 16 5.00 Very Low Very Low Very Low
Depression 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The C-fibre pathway was boosted by inflammatory sensitisation, thus further increasing the likelihood of PHS.
Positive_regulation (increasing) of PHS associated with c fibre and inflammation
1) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 1.37 Pain Relevance 1.00
The positive correlation between cold pain hyperalgesia and the occurrence of PHS in acute CRPS additionally confirms the hypothesis, that cold pain hyperalgesia, just like PHS, is caused by A-delta fibre degeneration as well as inflammation (Figure 5B).
Positive_regulation (caused) of PHS associated with pain, hyperalgesia, reflex sympathetic dystrophy and inflammation
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 2.12 Pain Relevance 1.48

General Comments

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