INT238793

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.01
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cbl) nucleus (Cbl) ligase activity (Cbl)
cytoplasm (Cbl) signal transducer activity (Cbl)
Anatomy Link Frequency
taste receptor cells 2
hepatocytes 1
rod bipolar cell 1
mononuclear phagocytes 1
Cbl (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 4 99.40 Very High Very High Very High
ischemia 12 83.68 Quite High
opiate 2 81.88 Quite High
opioid receptor 2 78.56 Quite High
Inflammation 5 60.40 Quite High
cytokine 2 59.36 Quite High
medulla 28 5.00 Very Low Very Low Very Low
trigeminal ganglion 12 5.00 Very Low Very Low Very Low
Bile 7 5.00 Very Low Very Low Very Low
parabrachial 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 98.68 Very High Very High Very High
Atherosclerosis 16 98.60 Very High Very High Very High
Targeted Disruption 115 98.30 Very High Very High Very High
Diabetes Mellitus 153 97.48 Very High Very High Very High
Toxicity 5 93.36 High High
Retina Disease 1 85.96 High High
Injury 25 84.68 Quite High
Cv Unclassified Under Development 12 83.68 Quite High
Hyperlipoproteinemia Type Ii 66 82.56 Quite High
Myocardial Infarction 9 75.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several investigators have shown that most type II taste receptor cells, which express the signal transduction molecules for bitter, sweet and umami, do not express synaptic markers or voltage gated calcium channels, whereas most type III cells express synaptic markers but no signal transduction genes for sweet, bitter or umami [12-16] and that ATP, which is released from type II cells upon stimulation by tastants can activate type III cells [17,18].
Neg (no) Gene_expression (express) of signal transduction in taste receptor cells associated with calcium channel
1) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.20 Pain Relevance 0.16
Several investigators have shown that most type II taste receptor cells, which express the signal transduction molecules for bitter, sweet and umami, do not express synaptic markers or voltage gated calcium channels, whereas most type III cells express synaptic markers but no signal transduction genes for sweet, bitter or umami [12-16] and that ATP, which is released from type II cells upon stimulation by tastants can activate type III cells [17,18].
Gene_expression (express) of signal transduction in taste receptor cells associated with calcium channel
2) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.22 Pain Relevance 0.17
Bhlhb4 could regulate expression of trophic factor or trophic signal transduction genes that promote rod bipolar cell survival specifically.
Gene_expression (expression) of signal transduction in rod bipolar cell
3) Confidence 0.03 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.33 Pain Relevance 0
A number of IP3Rs-binding proteins are known to regulate the IP3-Ca2+ signal cascade (Choe and Ehrlich 2006), and their differential distribution is thought to produce various signal transduction in various organs, although little is known about such regulators in taste cells.
Gene_expression (produce) of signal transduction
4) Confidence 0.02 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
RESEARCH DESIGN AND METHODS—To specifically dissect the impact of RAGE, homozygous RAGE-null mice and transgenic (Tg) mice expressing cytoplasmic domain-deleted RAGE (DN RAGE), in which RAGE-dependent signal transduction was deficient in endothelial cells or mononuclear phagocytes, were rendered diabetic with streptozotocin.
Gene_expression (deficient) of signal transduction in mononuclear phagocytes associated with targeted disruption and diabetes mellitus
5) Confidence 0.01 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453611 Disease Relevance 1.57 Pain Relevance 0.04
Serotype 8 virus achieved stable transduction and expression of the transgene in up to 85% of the hepatocytes.
Gene_expression (expression) of transduction in hepatocytes
6) Confidence 0.01 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.67 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox