INT238802

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.46
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp) extracellular space (Ager) plasma membrane (Ager)
cytoplasm (Ager)
Anatomy Link Frequency
neurons 1
Ager (Mus musculus)
Renbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 189 85.28 High High
cytokine 48 84.24 Quite High
Hippocampus 10 61.92 Quite High
Inflammatory response 8 39.36 Quite Low
Abeta 36 5.00 Very Low Very Low Very Low
ischemia 27 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 121 99.92 Very High Very High Very High
Myeloid Leukemia 66 99.62 Very High Very High Very High
Lung Cancer 21 98.68 Very High Very High Very High
Aging 11 96.36 Very High Very High Very High
Diabetes Mellitus 390 95.24 Very High Very High Very High
Neuroblastoma 4 95.04 Very High Very High Very High
Apoptosis 56 94.04 High High
Cancer 94 89.36 High High
Esophageal Cancer 3 87.52 High High
INFLAMMATION 200 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CML AGEs are specific AGE ligands of RAGE (11).
RAGE Binding (ligands) of AGE associated with myeloid leukemia
1) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.93 Pain Relevance 0
CML AGEs are specific AGE ligands of RAGE (11).
RAGE Binding (ligands) of AGE associated with myeloid leukemia
2) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.93 Pain Relevance 0
AGE products bind to RAGE, which is present in neurons and binds to amyloidogenic APP derivative A?
RAGE Binding (bind) of AGE in neurons
3) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.16 Pain Relevance 0.12
Furthermore, blocking AGE-RAGE interactions leads to diminished cell growth [186].
RAGE Binding (interactions) of AGE
4) Confidence 0.00 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.37 Pain Relevance 0.05
RAGE will bind to AGE-modified albumin but not nonglycated albumin [167].
RAGE Neg (not) Binding (bind) of AGE
5) Confidence 0.00 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.70 Pain Relevance 0
Furthermore, blocking AGE-RAGE interactions leads to diminished cell growth [186].
RAGE Binding (interactions) of AGE
6) Confidence 0.00 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.37 Pain Relevance 0.05

General Comments

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