INT238805

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.20
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (DSP, HSPB2) cytosol (HSPB2) mitochondrion (DSP)
structural molecule activity (DSP) nucleus (HSPB2) plasma membrane (DSP)
Anatomy Link Frequency
upper 1
DSP (Homo sapiens)
HSPB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 97.72 Very High Very High Very High
Angina 5 5.00 Very Low Very Low Very Low
diabetic neuropathy 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathy 115 100.00 Very High Very High Very High
Diabetes Mellitus 105 99.56 Very High Very High Very High
INFLAMMATION 10 97.72 Very High Very High Very High
Diabetes Complications 25 89.04 High High
Ocular Toxicity (including Many Sub-types) 35 86.08 High High
Nicotine Addiction 15 75.96 Quite High
Hypertension 10 75.60 Quite High
Shock 25 75.00 Quite High
Disease 5 66.40 Quite High
Cardiovascular Disease 35 57.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, this is the first study measuring sHSP27 in a large group of subjects, and the results provide evidence that sHSP27 levels are independently associated with DSP in type 1 diabetic patients.
DSP Binding (associated) of sHSP27 associated with neuropathy and diabetes mellitus
1) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 0.40 Pain Relevance 0
Final models, performed separately for each complication, showed that higher HSP27 values were associated with a more than twofold increased OR of DSP, which was statistically significant (OR 2.45 [95% CI 1.20–5.03]), even after further adjustment for AER values (2.41 [1.11–5.24]).
DSP Binding (associated) of HSP27 associated with neuropathy
2) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 0.72 Pain Relevance 0
CONCLUSIONS—In this large cohort of type 1 diabetic subjects, we found an independent association between sHSP27 and DSP.
DSP Binding (association) of sHSP27 associated with neuropathy and diabetes mellitus
3) Confidence 0.07 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453614 Disease Relevance 1.03 Pain Relevance 0.05
In logistic regression analysis, sHSP27 levels in the upper quartile were associated with a twofold increased odds ratio (OR) of DSP, independently of conventional risk factors, markers of inflammation, and AER (OR 2.41 [95% CI 1.11–5.24]).
DSP Binding (associated) of sHSP27 in upper associated with neuropathy and inflammation
4) Confidence 0.07 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453614 Disease Relevance 1.18 Pain Relevance 0.05
In this cross-sectional sample of type 1 diabetic patients from the EURODIAB Prospective Complications Study, we have provided the first evidence of an independent association between sHSP27 levels and DSP.
DSP Binding (association) of sHSP27 associated with neuropathy and diabetes mellitus
5) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 0.87 Pain Relevance 0.04

General Comments

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