INT238836

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 3.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RBP4) extracellular region (RBP4) embryo development (RBP4)
transmembrane transport (RBP4)
Anatomy Link Frequency
adipose tissue 8
RBP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 126 100.00 Very High Very High Very High
Obesity 175 99.84 Very High Very High Very High
Diabetes Mellitus 105 92.24 High High
Anaemia 35 91.44 High High
Necrosis 7 88.56 High High
Cancer 7 88.20 High High
Impaired Glucose Tolerance 21 84.64 Quite High
Iron-deficiency Anemia 7 79.92 Quite High
Targeted Disruption 7 75.28 Quite High
Disorder Of Lipid Metabolism 21 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, lactoferrin, a well-known iron transport protein and iron donor (24), led to significant RBP4 release in a dose-dependent manner and to increased RBP4 expression in adipose tissue explants.
Positive_regulation (led) of Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
1) Confidence 0.68 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.26 Pain Relevance 0
Interestingly, the lower the serum RBP4 concentration at follow-up the higher the increase in insulin sensitivity (r = ?
Positive_regulation (increase) of Gene_expression (concentration) of RBP4
2) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.26 Pain Relevance 0
Given the interactions between vitamin A and iron, we hypothesized that raised iron stores could be behind the association between increased serum RBP4 concentration and insulin resistance.
Positive_regulation (increased) of Gene_expression (resistance) of RBP4 associated with insulin resistance
3) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.69 Pain Relevance 0
Circulating RBP4 levels and adipose tissue RBP4 expression were raised in several different mouse models of obesity and insulin resistance.
Positive_regulation (Circulating) of Gene_expression (levels) of RBP4 in adipose tissue associated with obesity and insulin resistance
4) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.18 Pain Relevance 0
After 48 h of incubation, lactoferrin treatment led to a 1.32-fold higher RBP4 expression (P = 0.01) (Fig. 5B).
Positive_regulation (higher) of Gene_expression (expression) of RBP4
5) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.30 Pain Relevance 0
The iron donor lactoferrin led to increased dose-dependent adipose tissue release of RBP4 (2.4-fold, P = 0.005) and increased RBP4 expression, while apotransferrin and deferoxamine led to decreased RBP4 release.
Positive_regulation (increased) of Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
6) Confidence 0.49 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453621 Disease Relevance 0.52 Pain Relevance 0
Furthermore, lactoferrin, a well-known iron transport protein and iron donor (24), led to significant RBP4 release in a dose-dependent manner and to increased RBP4 expression in adipose tissue explants.
Positive_regulation (increased) of Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
7) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.25 Pain Relevance 0

General Comments

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