INT238855

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.00
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
muscle 6
adipose tissue 4
fat 2
skeletal muscle 2
adipocytes 2
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 46 96.44 Very High Very High Very High
agonist 41 95.88 Very High Very High Very High
noradrenaline 42 72.52 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1155 99.92 Very High Very High Very High
Hyperinsulinism 7 85.92 High High
Body Weight 7 52.24 Quite High
Sprains And Strains 7 41.32 Quite Low
Rheumatoid Arthritis 35 5.00 Very Low Very Low Very Low
Insulin Resistance 21 5.00 Very Low Very Low Very Low
Diabetes Mellitus 17 5.00 Very Low Very Low Very Low
Weight Loss 7 5.00 Very Low Very Low Very Low
Heart Rate Under Development 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A more distal defect in catecholamine signal transduction at the level of hormone-sensitive lipase (HSL, the rate-limiting enzyme for hydrolysis of stored TAGs) is observed in SC fat of obese women and is linked to decreased expression and activity of HSL [4].
Negative_regulation (decreased) of Gene_expression (expression) of HSL in fat associated with catecholamine and obesity
1) Confidence 0.39 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.75 Pain Relevance 0.09
This suggests that, at least in adipose tissue, a decreased HSL expression is a primary defect in obesity (31,32).
Negative_regulation (decreased) of Gene_expression (expression) of HSL in adipose tissue associated with obesity
2) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.95 Pain Relevance 0
To our knowledge, our data provide the first indication of a reduced muscle HSL protein expression in obese compared with lean subjects.
Negative_regulation (reduced) of Gene_expression (expression) of HSL protein in muscle associated with obesity
3) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.83 Pain Relevance 0
It is well known that expression of HSL is markedly decreased in subcutaneous adipocytes and differentiated adipocytes from obese subjects.
Negative_regulation (decreased) of Gene_expression (expression) of HSL in adipocytes associated with obesity
4) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.88 Pain Relevance 0
Despite higher mRNA levels, hormone-sensitive lipase protein expression decreased in both depots of the obese women.
Negative_regulation (decreased) of Gene_expression (expression) of hormone-sensitive lipase associated with obesity
5) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2804660 Disease Relevance 1.14 Pain Relevance 0.07
Depot-specific differences in HSL expression
Negative_regulation (differences) of Gene_expression (expression) of HSL
6) Confidence 0.33 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.70 Pain Relevance 0.06
-adrenergic stimulation to deal with a reduced total HSL protein expression, increasing muscle HSL activity to a level comparable with lean subjects.
Negative_regulation (reduced) of Gene_expression (expression) of HSL protein in muscle
7) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.33 Pain Relevance 0
Expression of HSL protein and phosphorylation of HSL Ser563, Ser565, and Ser659 was detected by Western blotting on the muscle lysates.
Negative_regulation (detected) of Gene_expression (Expression) of HSL protein in muscle
8) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.07 Pain Relevance 0
This suggests that, at least in adipose tissue, a decreased HSL expression is a primary defect in obesity (31,32).
Negative_regulation (decreased) of Gene_expression (expression) of HSL in adipose tissue associated with obesity
9) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.95 Pain Relevance 0
To obtain more information on the underlying mechanism at the molecular level, we measured skeletal muscle HSL protein expression and serine phosphorylation on Ser563, Ser565, and Ser659.
Negative_regulation (measured) of Gene_expression (expression) of HSL protein in skeletal muscle
10) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

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