INT238857

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAA1) signal transduction (PRKAA1) nucleus (PRKAA1)
intracellular (PRKAA1) response to stress (PRKAA1) cytoplasm (PRKAA1)
Anatomy Link Frequency
muscle 1
PRKAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 5.00 Very Low Very Low Very Low
Catecholamine 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 198 99.12 Very High Very High Very High
Hyperinsulinism 2 87.48 High High
Weight Loss 2 63.00 Quite High
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Insulin Resistance 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the obese insulin-resistant state is characterized by a reduced muscle glycerol release during baseline fasting conditions, which was accompanied by a lower HSL protein expression and phosphorylation on the PKA target sites Ser563 and Ser659 and on the AMPK target site Ser565.
Phosphorylation (phosphorylation) of AMPK target site in muscle associated with obesity
1) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.73 Pain Relevance 0
Furthermore, our data suggest that phosphorylation of HSL on the PKA target sites Ser563 and Ser659, and on the AMPK target site Ser565, was lower in obese than in lean subjects.
Phosphorylation (phosphorylation) of AMPK target site associated with obesity
2) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 1.00 Pain Relevance 0

General Comments

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