INT238857

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.73 Pain Relevance 0

cytosol (PRKAA1) signal transduction (PRKAA1) nucleus (PRKAA1) intracellular (PRKAA1) response to stress (PRKAA1) cytoplasm (PRKAA1)

Anatomy Link Frequency muscle 1 PRKAA1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 10 5.00 Catecholamine 8 5.00 anesthesia 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Obesity 198 99.12 Hyperinsulinism 2 87.48 Weight Loss 2 63.00 Rheumatoid Arthritis 10 5.00 Insulin Resistance 6 5.00 Diabetes Mellitus 4 5.00 Sprains And Strains 2 5.00 Heart Rate Under Development 2 5.00 Body Weight 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, the obese insulin-resistant state is characterized by a reduced muscle glycerol release during baseline fasting conditions, which was accompanied by a lower HSL protein expression and phosphorylation on the PKA target sites Ser563 and Ser659 and on the AMPK target site Ser565.

Phosphorylation (phosphorylation) of AMPK target site in muscle associated with obesity

1) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.73 Pain Relevance 0

Furthermore, our data suggest that phosphorylation of HSL on the PKA target sites Ser563 and Ser659, and on the AMPK target site Ser565, was lower in obese than in lean subjects.

Phosphorylation (phosphorylation) of AMPK target site associated with obesity

2) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 1.00 Pain Relevance 0

General Comments

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