INT238860

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
muscle 2
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 25 5.00 Very Low Very Low Very Low
Catecholamine 20 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 495 99.84 Very High Very High Very High
Hyperinsulinism 5 87.48 High High
Sprains And Strains 5 40.12 Quite Low
Diabetes Mellitus 10 12.00 Low Low
Rheumatoid Arthritis 25 5.00 Very Low Very Low Very Low
Insulin Resistance 15 5.00 Very Low Very Low Very Low
Weight Loss 5 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the reduced phosphorylation of HSL on these two sites may not have been important in determining the blunted baseline lipolysis in obese subjects.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of HSL associated with obesity
1) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.59 Pain Relevance 0
Nevertheless, the reduced absolute number of HSL molecules phosphorylated on Ser659 may at least partly explain the blunted baseline glycerol release in obese compared with lean subjects.
Negative_regulation (reduced) of Phosphorylation (phosphorylated) of HSL associated with obesity
2) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.92 Pain Relevance 0
Furthermore, our data suggest that phosphorylation of HSL on the PKA target sites Ser563 and Ser659, and on the AMPK target site Ser565, was lower in obese than in lean subjects.
Negative_regulation (lower) of Phosphorylation (phosphorylation) of HSL associated with obesity
3) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 1.00 Pain Relevance 0
Expression of HSL protein and phosphorylation of HSL Ser563, Ser565, and Ser659 was detected by Western blotting on the muscle lysates.
Negative_regulation (detected) of Phosphorylation (phosphorylation) of HSL Ser563 in muscle
4) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.07 Pain Relevance 0
Nevertheless, the reduced absolute number of HSL molecules phosphorylated on Ser659 may at least partly explain the blunted baseline glycerol release in obese compared with lean subjects.
Negative_regulation (number) of Phosphorylation (phosphorylated) of HSL associated with obesity
5) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.92 Pain Relevance 0

General Comments

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