INT238863

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
muscle 4
adipocytes 2
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 15 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 297 100.00 Very High Very High Very High
Hyperinsulinism 3 77.36 Quite High
Weight Loss 3 65.00 Quite High
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Insulin Resistance 9 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Heart Rate Under Development 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well known that expression of HSL is markedly decreased in subcutaneous adipocytes and differentiated adipocytes from obese subjects.
Regulation (differentiated) of Gene_expression (expression) of HSL in adipocytes associated with obesity
1) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.90 Pain Relevance 0
In conclusion, the obese insulin-resistant state is characterized by a reduced muscle glycerol release during baseline fasting conditions, which was accompanied by a lower HSL protein expression and phosphorylation on the PKA target sites Ser563 and Ser659 and on the AMPK target site Ser565.
Regulation (accompanied) of Gene_expression (expression) of HSL protein in muscle associated with obesity
2) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.73 Pain Relevance 0
Muscle HSL protein expression was significantly lower in obese compared with lean subjects (P = 0.004) and did not change during ?
Neg (not) Regulation (change) of Gene_expression (expression) of HSL protein in Muscle associated with obesity
3) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.99 Pain Relevance 0

General Comments

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