INT238865

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.64
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
skeletal muscle 4
adipocyte 4
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 44 80.00 Quite High
agonist 44 62.16 Quite High
noradrenaline 28 37.84 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1100 99.84 Very High Very High Very High
Weight Loss 8 40.16 Quite Low
Diabetes Mellitus 18 25.56 Quite Low
Insulin Resistance 24 14.44 Low Low
Rheumatoid Arthritis 40 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Heart Rate Under Development 8 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Hyperinsulinism 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of correlation between protein expression and mRNA level suggests that HSL may be regulated at some post-transcriptional levels (such as phosphorylation which activates HSL activity and induces HSL translocation from the cytosol to the lipid droplet upon adipocyte stimulation [3]).
Positive_regulation (activates) of Phosphorylation (phosphorylation) of HSL in adipocyte
1) Confidence 0.45 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.69 Pain Relevance 0.04
The absence of correlation between protein expression and mRNA level suggests that HSL may be regulated at some post-transcriptional levels (such as phosphorylation which activates HSL activity and induces HSL translocation from the cytosol to the lipid droplet upon adipocyte stimulation [3]).
Positive_regulation (induces) of Phosphorylation (phosphorylation) of HSL in adipocyte
2) Confidence 0.45 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.70 Pain Relevance 0.04
Interestingly, this was accompanied by an increase in HSL Ser659 phosphorylation in obese subjects during ISO compared with baseline (P = 0.008).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of HSL Ser659 associated with obesity
3) Confidence 0.39 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453623 Disease Relevance 0.63 Pain Relevance 0.03
In human skeletal muscle, changes in AMPK activity during exercise were also associated with an increased HSL Ser565 phosphorylation, but this was not accompanied by an increased HSL activity, suggesting that AMPK can phosphorylate HSL on Ser565 but that AMPK is of minor importance as a regulator of HSL activity in human skeletal muscle during exercise (11).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of HSL Ser565 in skeletal muscle
4) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.13 Pain Relevance 0.11
This is in accordance with previous studies, in which HSL Ser563 phosphorylation was not increased during exercise despite an increase in circulating epinephrine (11,13).
Neg (not) Positive_regulation (increased) of Phosphorylation (phosphorylation) of HSL Ser563
5) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.33 Pain Relevance 0
In the present study, HSL Ser659 phosphorylation significantly increased during ?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of HSL Ser659
6) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.31 Pain Relevance 0
It can be speculated that obese subjects increase HSL Ser659 phosphorylation during ?
Positive_regulation (increase) of Phosphorylation (phosphorylation) of HSL Ser659 associated with obesity
7) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.35 Pain Relevance 0
In contrast to lean subjects, an increased HSL Ser659 phosphorylation was observed in skeletal muscle of obese subjects during ?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of HSL Ser659 in skeletal muscle associated with obesity
8) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.83 Pain Relevance 0
Finally, phosphorylation of the PKA target site Ser563 on HSL did not increase significantly during ?
Neg (not) Positive_regulation (increase) of Phosphorylation (phosphorylation) of HSL
9) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.34 Pain Relevance 0
Finally, phosphorylation of the PKA target site Ser563 on HSL did not increase significantly during ?
Positive_regulation (on) of Phosphorylation (phosphorylation) of HSL
10) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.34 Pain Relevance 0

General Comments

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