INT238866

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
adipocyte 2
central nervous system 2
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 10 98.48 Very High Very High Very High
Central nervous system 2 96.58 Very High Very High Very High
tolerance 1 67.92 Quite High
agonist 5 56.16 Quite High
Catecholamine 5 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 106 95.84 Very High Very High Very High
Diabetes Mellitus 2 10.96 Low Low
Weight Loss 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low
Insulin Resistance 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known from studies with purified bovine adipocyte HSL (15) and in different cell lines transfected with wild-type and mutant forms of HSL (14) that ?
Positive_regulation (transfected) of Gene_expression (transfected) of HSL in adipocyte
1) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.23 Pain Relevance 0.03
The lipolytic mechanisms associated with caffeine ingestion include the following [16]: 1) central nervous system stimulation resulting in an increase in circulating epinephrine, 2) an inhibition in intracellular phosphodiesterase activity leading to sustained intracellular cAMP and activated perilipin and HSL levels, and 3) the antagonism of peripheral adenosine (A1) receptors which further increases intracellular cAMP levels [17].
Positive_regulation (activated) of Gene_expression (levels) of HSL in central nervous system associated with adenocard and central nervous system
2) Confidence 0.05 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2579279 Disease Relevance 0.14 Pain Relevance 0.21

General Comments

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