INT238869

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
fat 2
adipocyte 2
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 10 96.44 Very High Very High Very High
agonist 7 23.92 Low Low
noradrenaline 14 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 253 99.52 Very High Very High Very High
Diabetes Mellitus 3 31.16 Quite Low
Insulin Resistance 3 20.04 Low Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Hyperinsulinism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A more distal defect in catecholamine signal transduction at the level of hormone-sensitive lipase (HSL, the rate-limiting enzyme for hydrolysis of stored TAGs) is observed in SC fat of obese women and is linked to decreased expression and activity of HSL [4].
Negative_regulation (decreased) of Positive_regulation (activity) of HSL in fat associated with catecholamine and obesity
1) Confidence 0.39 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.75 Pain Relevance 0.09
In vitro studies on purified bovine adipocyte HSL have shown that AMP-activated protein kinase (AMPK) phosphorylates HSL on Ser565, thereby abolishing PKA-induced HSL activation (15).
Negative_regulation (abolishing) of Positive_regulation (activation) of HSL in adipocyte
2) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.06 Pain Relevance 0.11

General Comments

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