INT23889

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Context Info
Confidence 0.11
First Reported 1987
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Calca, Tacr1) aging (Calca) intracellular (Calca)
response to stress (Tacr1) signal transducer activity (Tacr1) extracellular space (Calca)
Anatomy Link Frequency
dorsal horn 4
Calca (Rattus norvegicus)
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 8 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
spinal dorsal horn 4 99.96 Very High Very High Very High
Spinal cord 2 94.84 High High
Hyperalgesia 2 91.28 High High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Hyperalgesia 2 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats.
Calcitonin gene-related peptide Positive_regulation (potentiating) of Localization (release) of substance P in dorsal horn associated with nociception, spinal dorsal horn, substance p and calcitonin gene-related peptide
1) Confidence 0.11 Published 1987 Journal Brain Res. Section Title Doc Link 2435372 Disease Relevance 0.18 Pain Relevance 1.02
These findings suggest that in the rat spinal dorsal horn, CGRP potentiates the release of substance P from the primary afferent terminal and promotes the transmission of nociceptive information induced by mechanical noxious stimuli.
CGRP Positive_regulation (potentiates) of Localization (release) of substance P in dorsal horn associated with nociception, spinal dorsal horn and substance p
2) Confidence 0.11 Published 1987 Journal Brain Res. Section Abstract Doc Link 2435372 Disease Relevance 0.26 Pain Relevance 0.64

General Comments

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