INT2389

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Context Info
Confidence 0.61
First Reported 1979
Last Reported 2010
Negated 12
Speculated 8
Reported most in Abstract
Documents 86
Total Number 94
Disease Relevance 31.23
Pain Relevance 28.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
platelet 5
blood 2
plasma 1
cleavage 1
brains 1
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 374 100.00 Very High Very High Very High
aspirin 95 100.00 Very High Very High Very High
COX2 55 100.00 Very High Very High Very High
Paracetamol 41 100.00 Very High Very High Very High
cOX1 39 100.00 Very High Very High Very High
Analgesic 39 100.00 Very High Very High Very High
cytokine 23 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
lidocaine 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 226 100.00 Very High Very High Very High
Breast Cancer 61 100.00 Very High Very High Very High
Colorectal Cancer 12 99.92 Very High Very High Very High
Neurodegenerative Disease 2 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 44 99.56 Very High Very High Very High
Hyperemia 6 99.44 Very High Very High Very High
Cancer 192 99.40 Very High Very High Very High
Rheumatoid Arthritis 11 99.38 Very High Very High Very High
Asthma 6 99.32 Very High Very High Very High
Neurogenic Inflammation 5 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have determined its effect on platelet cyclooxygenase in man.
Spec (determined) Regulation (effect) of cyclooxygenase in platelet
1) Confidence 0.61 Published 1996 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 8866627 Disease Relevance 0.09 Pain Relevance 0.24
The effects of the same inhibitors on platelet PGHS-1 activity were assessed by allowing 1-ml whole blood samples to clot at 37 degrees C for 1 h in the presence of the compounds and measuring immunoreactive TXB2 levels in serum.
Regulation (effects) of platelet PGHS-1 in blood
2) Confidence 0.60 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.24 Pain Relevance 0.32
RA counteracted the inflammatory regulation of cyclooxygenase (COX)-2 mRNA and protein in astrocytes and thereby reduced the synthesis of PGE(2) by approximately 60%.
Regulation (regulation) of cyclooxygenase in astrocytes associated with inflammation and rheumatoid arthritis
3) Confidence 0.60 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18394023 Disease Relevance 0.86 Pain Relevance 0.29
The major metabolite of tartrazine, sulfanilic acid, also had no inhibitory effect on the sheep seminal vesicle cyclooxygenase.
Neg (no) Regulation (effect) of cyclooxygenase in seminal vesicle
4) Confidence 0.46 Published 1979 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 429706 Disease Relevance 0.26 Pain Relevance 0.22
Cyclooxygenase inhibitors acetylsalicylic acid and indomethacin do not affect capsaicin-induced neurogenic inflammation in human skin.
Neg (not) Regulation (affect) of Cyclooxygenase in skin associated with aspirin, inflammation, qutenza and neurogenic inflammation
5) Confidence 0.45 Published 1993 Journal Agents Actions Section Title Doc Link 8317315 Disease Relevance 0.76 Pain Relevance 1.02
Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity.
Regulation (effect) of cyclooxygenase in blood associated with aspirin
6) Confidence 0.45 Published 1994 Journal Stroke Section Title Doc Link 8073456 Disease Relevance 0.26 Pain Relevance 0.23
METHODS: The effect of a single dose of indomethacin and of two other cyclooxygenase inhibitors (aspirin and sulindac) on the cerebral circulation was measured using transcranial Doppler ultrasonography of the middle cerebral artery.
Regulation (effect) of cyclooxygenase in middle cerebral artery
7) Confidence 0.45 Published 1994 Journal Stroke Section Body Doc Link 8073456 Disease Relevance 0 Pain Relevance 0
The His-tags are located one and two amino acids beyond the signal peptide cleavage sites of PGHS-1 and PGHS-2, respectively, positions that do not affect their activities or sensitivities to nonsteroidal anti-inflammatory drugs.
Neg (not) Regulation (affect) of PGHS-1 in cleavage associated with inflammation and cinod
8) Confidence 0.45 Published 2000 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10683267 Disease Relevance 0.18 Pain Relevance 0.18
Effect of cyclooxygenase inhibitor on excessive sputum.
Regulation (Effect) of cyclooxygenase in sputum
9) Confidence 0.45 Published 1991 Journal Fukuoka Igaku Zasshi Section Title Doc Link 1905674 Disease Relevance 0.51 Pain Relevance 0.21
Regulation of cyclooxygenase activity by metamizol.
Regulation (Regulation) of cyclooxygenase associated with cox1
10) Confidence 0.45 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10493111 Disease Relevance 0 Pain Relevance 0.10
L-745,337, NS-398 and SC58125 achieved selective inhibition of monocyte PGHS-2 (IC50, PGHS-1/IC50, PGHS-2: < 100) and may provide adequate tools to test the contribution of this novel pathway of arachidonate metabolism to human inflammatory disease and to verify the hypothesis that the common side-effects of NSAIDs are due primarily to their ability to affect the activity of PGHS-1.
Regulation (affect) of PGHS-1 in monocyte associated with inflammation, cinod and disease
11) Confidence 0.44 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.27 Pain Relevance 0.26
Therefore, it seems possible that these compounds act on PTGS1/2.
Spec (seems) Regulation (act) of PTGS1
12) Confidence 0.43 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0.09 Pain Relevance 0.30
[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia].
Regulation (Effect) of cyclooxygenase associated with inflammation, cancer and cox1
13) Confidence 0.38 Published 2001 Journal Medicina (B Aires) Section Title Doc Link 11721323 Disease Relevance 0.37 Pain Relevance 0.42
The effects of cyclooxygenase inhibitors on thromboxane-mediated vasoconstriction in human placental arteries were studied in the isolated perfused fetoplacental cotyledon.
Regulation (effects) of cyclooxygenase associated with increased venous pressure under development
14) Confidence 0.38 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1415690 Disease Relevance 0.16 Pain Relevance 0.04
The widespread consumption of diets rich in anthocyanin and catechin content prompted the evaluation of their in vitro inhibitory effects on cyclooxygenase (COX) enzymes and on the proliferation of human cancer cell lines.
Regulation (effects) of cyclooxygenase associated with cancer
15) Confidence 0.36 Published 2003 Journal Nutr Cancer Section Abstract Doc Link 12925310 Disease Relevance 0.17 Pain Relevance 0
In addition, the biochemical properties of these isozymes, and the differential regulation of the PGHS-1 and PGHS-2 genes, will be examined.
Regulation (regulation) of PGHS-1
16) Confidence 0.34 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631045 Disease Relevance 0.43 Pain Relevance 0.93
Due to the possible involvement of endothelin in headache disorders, the objective of this study was to verify the effects of lithium and cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid and naproxen) on endothelin-1 (ET-1)-induced contractions in isolated human temporal arteries and porcine ophthalmic arteries.
Regulation (effects) of cyclooxygenase associated with aspirin and headache
17) Confidence 0.32 Published 1992 Journal Headache Section Abstract Doc Link 1468903 Disease Relevance 0.61 Pain Relevance 0.64
Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging.
Regulation (target) of Cyclooxygenase associated with cox2 and imagery
18) Confidence 0.30 Published 2003 Journal Mol Imaging Biol Section Title Doc Link 14630509 Disease Relevance 0.18 Pain Relevance 0.42
The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension.
Regulation (effects) of cyclooxygenase in uterine associated with analgesic and antinociceptive
19) Confidence 0.29 Published 2004 Journal Brain Res. Section Title Doc Link 15451374 Disease Relevance 0.61 Pain Relevance 0.92
Prostaglandin H synthase-1 and -2 (PGHS-1 and -2) catalyze the committed step in prostaglandin synthesis and are targets for nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin.
Regulation (targets) of PGHS-1 associated with aspirin, inflammation and cinod
20) Confidence 0.27 Published 2000 Journal Science Section Abstract Doc Link 10988074 Disease Relevance 0.10 Pain Relevance 0.25

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